Thbd | Fetomodulin/Cd141 Rabbit pAb(bs-0525R)-50ul/100ul/200ul产品图
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Thbd | Fetomodulin/Cd141 Rabbi

t pAb(bs-0525R)-50ul/100ul/200ul
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  • 2026年10月13日
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    北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-0525R
    英文名称Thrombomodulin Rabbit pAb
    中文名称血栓调节蛋白抗体
    英文别名CD 141; CD141; CD141 antigen; Fetomodulin; THBD; THRM; TM; AHUS 6; AHUS6; BDCA 3; BDCA3; THPH12; TRBM_HUMAN.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Mouse, Rat (Dog, Cow)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from mouse Thrombomodulin
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量61 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cardiovascular > Angiogenesis > Endothelial Cell Markers

    Cardiovascular > Blood > Coagulation > Regulatory

    Cardiovascular > Cardiovascular Markers > Cell Markers > Endothelial Cells

    Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > Adhesion molecules ELISA kits

    Stem Cells > Endothelial Progenitors > Endothelial Markers

    亚细胞定位Membrane; Single-pass type I membrane protein.
    组织特异性Endothelial cells are unique in synthesizing thrombomodulin.
    翻译后修饰N-glycosylated.
    _x000D_ The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
    相似性Contains 1 C-type lectin domain.
    _x000D_ Contains 6 EGF-like domains.
    功能Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Thrombomodulin, TM is cell surface glycoprotein; plays an important role in the protein C anticoagulant pathway. It located in a vein, artery and capillary endothelial cells on the surface of plasma membrane protein. It is generally believed: TM vascular endothelial injury is an important parameter is the thrombin receptor, known in a variety of normal human tissues, can also be expressed in many tumors, TM may be similar to the E-cadherin,and is a lectin Like activity of a new class of members of the cell adhesion molecules. CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    产品细节图片1
    （IHC）Immunohistochemistry_x000D_ Tissue/cell: human kidney tissue; 4% P‌‌araformaldehyde-fixed and paraffin-embedded;
    _x000D_ Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
    _x000D_ Incubation: Anti-Thrombomodulin Polyclonal Antibody, Unconjugated(bs-0525R) 1:300, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
    _x000D_ _x000D_
    产品细节图片2
    Sample:
    _x000D_ Lane 1: Testis (Mouse) Tissue Lysate at 40 ug
    _x000D_ Lane 2: NIH/3T3 (Mouse) Cell Lysate at 30 ug
    _x000D_ Lane 3: Testis (Rat) Tissue Lysate at 40 ug
    _x000D_ Lane 4: A431 (Human) Cell Lysate at 30 ug
    _x000D_ Lane 5: Huvec (Human) Cell Lysate at 30 ug
    _x000D_ Lane 6: A549 (Human) Cell Lysate at 30 ug
    _x000D_ Primary: Anti-Thrombomodulin (bs-0525R) at 1/1000 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 61 kD
    _x000D_ Observed band size: 120 kD

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    图标文献和实验
    该产品被引用文献
    [1]Jingui Shenqi Wan alleviates bone loss induced by primary osteoporosis by inhibiting osteoblast pyroptosis.
    PMID:39910562J Orthop Surg Res2025-02
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    Thbd | Fetomodulin/Cd141 Rabbit pAb(bs-0525R)-50ul/100ul/200ul
    ￥1180 - 2800