Thrombomodulin Rabbit pAb(bs-0525R)-50ul/100ul/200ul
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Thrombomodulin Rabbit pAb(bs-0

525R)-50ul/100ul/200ul
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  • ￥1180 - 2800
  • Bioss已认证
  • bs-0525R
  • 2025年10月24日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-0525R
    英文名称Thrombomodulin Rabbit pAb
    中文名称血栓调节蛋白抗体
    英文别名CD 141; CD141; CD141 antigen; Fetomodulin; THBD; THRM; TM; AHUS 6; AHUS6; BDCA 3; BDCA3; THPH12; TRBM_HUMAN.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Mouse, Rat (Dog, Cow)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from mouse Thrombomodulin
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量61 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cardiovascular > Angiogenesis > Endothelial Cell Markers

    Cardiovascular > Blood > Coagulation > Regulatory

    Cardiovascular > Cardiovascular Markers > Cell Markers > Endothelial Cells

    Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > Adhesion molecules ELISA kits

    Stem Cells > Endothelial Progenitors > Endothelial Markers

    亚细胞定位Membrane; Single-pass type I membrane protein.
    组织特异性Endothelial cells are unique in synthesizing thrombomodulin.
    翻译后修饰N-glycosylated.
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
    相似性Contains 1 C-type lectin domain.
    Contains 6 EGF-like domains.
    功能Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Thrombomodulin, TM is cell surface glycoprotein; plays an important role in the protein C anticoagulant pathway. It located in a vein, artery and capillary endothelial cells on the surface of plasma membrane protein. It is generally believed: TM vascular endothelial injury is an important parameter is the thrombin receptor, known in a variety of normal human tissues, can also be expressed in many tumors, TM may be similar to the E-cadherin,and is a lectin Like activity of a new class of members of the cell adhesion molecules. CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    Thrombomodulin Rabbit pAb(bs-0
    （IHC）Immunohistochemistry Tissue/cell: human kidney tissue; 4% P‌‌araformaldehyde-fixed and paraffin-embedded;
    Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
    Incubation: Anti-Thrombomodulin Polyclonal Antibody, Unconjugated(bs-0525R) 1:300, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
    Thrombomodulin Rabbit pAb(bs-0
    Sample:
    Lane 1: Testis (Mouse) Tissue Lysate at 40 ug
    Lane 2: NIH/3T3 (Mouse) Cell Lysate at 30 ug
    Lane 3: Testis (Rat) Tissue Lysate at 40 ug
    Lane 4: A431 (Human) Cell Lysate at 30 ug
    Lane 5: Huvec (Human) Cell Lysate at 30 ug
    Lane 6: A549 (Human) Cell Lysate at 30 ug
    Primary: Anti-Thrombomodulin (bs-0525R) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 61 kD
    Observed band size: 120 kD

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    图标文献和实验
    该产品被引用文献

    [IF={{ 6.1 }}] {Jun Zhang. et al.Parthenolide improves sepsis-induced coagulopathy by inhibiting mitochondrial-mediated apoptosis in vascular endothelial cells through BRD4/BCL-xL pathway.JOURNAL OF TRANSLATIONAL MEDICINE.2025 Jan 17;23(1):80.} {} {Rat}

    [IF={{ 6.1 }}] {Yiyan Xie. et al. Portable pH meter-based competitive immunoassay of E-selectin using urease-encapsulated metal-organic frameworks. TALANTA. 2025 Jan;:127613} {} {}

    [IF={{ 5.3 }}] {Luo Peng. et al. Microvolumetric determination of thrombomodulin based on competitive immunoreaction using a portable glucometer. MICROCHIM ACTA. 2024 Oct;191(10):1-10} {} {}

    [IF={{ 3.905 }}] {Weifeng Hu. et al. Bone marrow-derived mesenchymal stem cells transplantation attenuates renal fibrosis following acute kidney injury by repairing the peritubular capillaries. Exp Cell Res. 2022 Feb;411:112983} {IHC} {Rat}

    [IF={{ 3.508 }}] {Juin-Hong Cherng. et al. Hemostasis and Anti-Inflammatory Abilities of AuNPs-Coated Chitosan Dressing for Burn Wounds. J PERS MED. 2022 Jul;12(7):1089} {IHC} {Rat}

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    Thrombomodulin Rabbit pAb(bs-0525R)-50ul/100ul/200ul
    ￥1180 - 2800