TNFRSF25 | APO3/DDR3 Rabbit pAb(bs-0421R)-50ul/100ul/200ul产品图
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TNFRSF25 | APO3/DDR3 Rabbit pA

b(bs-0421R)-50ul/100ul/200ul
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  • bs-0421R
  • 2026年10月13日
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    北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-0421R
    英文名称DR3 Rabbit pAb
    中文名称死亡受体3抗体
    英文别名Apo 3; Apo3; Apo-3; Apoptosis inducing receptor AIR; Apoptosis inducing receptor; Apoptosis mediating receptor; Apoptosis mediating receptor DR3; Apoptosis mediating receptor TRAMP; DDR 3; DDR3; Death domain receptor 3; Death Receptor 3; Death receptor beta; DR 3; LARD; Lymphocyte associated receptor of death; TNFRSF 12; TNFRSF 25; TNFRSF12; TNFRSF25; TR 3; TR3; TRAMP; Translocating chain association membrane protein; Tumor necrosis factor receptor superfamily member 12; Tumor necrosis factor receptor superfamily member 25; WSL 1; WSL; WSL LR; WSL1; WSL1 protein; WSLLR; TNR25_HUMAN.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Mouse, Rat (Human)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human DR3
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量43 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cell Biology > Apoptosis > Receptors > Death Receptors

    Signal Transduction > Signaling Pathway > Nuclear Signaling > NFkB Pathway

    亚基Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4.
    亚细胞定位Isoform 1: Cell membrane; Single-pass type I membrane protein.
    Isoform 2: Cell membrane; Single-pass type I membrane protein.
    Isoform 9: Cell membrane; Single-pass type I membrane protein.
    Isoform 11: Cell membrane; Single-pass type I membrane protein.
    Isoform 3: Secreted.
    Isoform 4: Secreted.
    Isoform 5: Secreted.
    Isoform 6: Secreted.
    Isoform 7: Secreted.
    Isoform 8: Secreted.
    Isoform 10: Secreted.
    Isoform 12: Secreted.
    组织特异性Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.
    翻译后修饰Glycosylated (Probable).
    相似性Contains 1 death domain._x000D_
    Contains 4 TNFR-Cys repeats.
    功能Receptor for TNFSF12/APO3L/TWEAK. Interacts directlywith the adapter TRADD. Mediates activation of NF-kappa-B andinduces apoptosis. May play a role in regulating lymphocytehomeostasis.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    产品细节图片1
    Sample:
    _x000D_ Lane 1: Spleen (Mouse) Lysate at 40 ug
    _x000D_ Lane 2: Thymus (Mouse) Lysate at 40 ug
    _x000D_ Lane 3: Lymph node (Mouse) Lysate at 40 ug
    _x000D_ Lane 4: Thymus (Rat) Lysate at 40 ug
    _x000D_ Primary: Anti-DR3 (bs-0421R) at 1/1000 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 50 kD
    _x000D_ Observed band size: 50 kD
    产品细节图片2
    P‌‌araformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (DR3) Polyclonal Antibody, Unconjugated (bs-0421R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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    图标文献和实验
    该产品被引用文献

    [IF=8.4] Zhu Yi-pan. et al. TNFSF15 alleviates myeloid-derived suppressor cell-mediated cancer immunosuppression in mice. ACTA PHARMACOL SIN. 2025 Sep;:1-11 WB Mouse

    [IF=3.71] Ślebioda, Tomasz Jerzy, et al. "TL1A as a potential local inducer of IL17A Expression in colon mucosa of inflammatory bowel disease patients."Scandinavian Journal of Immunology (2015). IHC ="Human"

    [IF=12.2] Sen Li. et al. Quinic acid alleviates high-fat diet-induced neuroinflammation by inhibiting DR3/IKK/NF-κB signaling via gut microbial tryptophan metabolites. GUT MICROBES. 2024 Jul WB Mouse

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    TNFRSF25 | APO3/DDR3 Rabbit pAb(bs-0421R)-50ul/100ul/200ul
    ￥1180 - 2800