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RANK Rabbit pAb(bs-2695R)-50ul

/100ul/200ul
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  • ￥1180 - 2800
  • Bioss已认证
  • bs-2695R
  • 2025年10月24日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-2695R
    英文名称RANK Rabbit pAb
    中文名称核转录因子NF-κB受体抗体(核因子kB受体活化因子)
    英文别名TNFRSF11A; CD265; CD265 antigen; Activator of NFKB; EOF; FEO; mRANK; NFKB activator; ODFR; OFE; Osteoclast differentiation factor receptor; PDB 2; Receptor activator of NF KB; receptor activator of nuclear factor kappa B; TNFRSF 11A; TNFSF11; TRANCE R; RANK receptor; TNR11_HUMAN.
    产品应用ICC/IF=1:50-100, Flow-Cyt=1μg /test

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human RANK
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量66 kDa
    实际分子量82-90kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    亚细胞定位Membrane.
    组织特异性Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.
    相似性Contains 4 TNFR-Cys repeats.
    功能Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]

     

    应用推荐稀释比例
    {ICC/IF}{1:50-100}
    {Flow-Cyt}{1μg /test}

     

    产品细节图片1
    The MJ (H) cells were incubated in 5%BSA to block non-specific protein-protein interactions (30 min at r.t.) , followed by secondary antibody incubation for 40 min at room temperature. Primary Antibody (green): Rabbit Anti-RANK antibody (bs-2695R): 1 μg/10^6 cells; Isotype Control (orange): Rabbit IgG (bs-0295P). Blank control (black): PBS. Acquisition of 20,000 events was performed.
    产品细节图片2
    4% P‌‌araformaldehyde-fixed MJ (H) cell; Antibody incubation with (RANK) polyclonal Antibody, unconjugated (bs-2695R) 1:100, 90 min at 37°C; followed by conjugated Goat Anti-Rabbit IgG antibody (green, bs-60295G-BF488) at 37°C for 90 min, DAPI (blue, C02-04002) was used to stain the cell nuclei. PBS instead of the primary antibody was used as the blank control.

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    图标文献和实验
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    [IF={{ 9 }}] {Zhang Ying. et al. Clinical-mediated discovery of pyroptosis in CD8+ T cell and NK cell reveals melanoma heterogeneity by single-cell and bulk sequence. CELL DEATH DIS. 2023 Aug;14(8):1-14} {IHC} {Human}

    [IF={{ 8.2 }}] {Dating Pei. et al. Modulation of macrophage polarization by secondary cross-linked hyaluronan-dopamine hydrogels. INT J BIOL MACROMOL. 2024 Jun;270:132417} {WB} {Mouse}

    [IF={{ 5.923 }}] {Nanami Nakamura. et al. Possible Action of Olaparib for Preventing Invasion of Oral Squamous Cell Carcinoma In Vitro and In Vivo. Int J Mol Sci. 2022 Jan;23(5):2527} {WB} {Mouse}

    [IF={{ 5.115 }}] {Yuan L et al. La2O3 Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2/ARE Signaling Pathway in Kunming Mice. Int J Nanomedicine. 2020 May 14;15:3415-3431.} {IHC} {Mouse}

    [IF={{ 5 }}] {Xu Yuxiang. et al. ACE2 Alleviates Microglia Neuroinflammation by RANK-RANKL-OPG Axis in Parkinson’s Disease. INFLAMMATION. 2025 Jul;:1-15} {WB} {Mouse}

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    文献支持
    RANK Rabbit pAb(bs-2695R)-50ul/100ul/200ul
    ￥1180 - 2800