CASP8 | Caspase-8 Mouse mAb(bsm-33190M)-50ul/100ul/200ul/200ug产品图
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CASP8 | Caspase-8 Mouse mAb(bs

m-33190M)-50ul/100ul/200ul/200ug
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  • bsm-33190M
  • 2026年10月13日
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    北京博奥森生物技术有限公司
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      50ul/100ul/200ul/200ug

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    规格：200ug产品价格：￥5600.0
    产品编号bsm-33190M
    英文名称Caspase 8 Mouse mAb
    中文名称半胱氨酸蛋白酶8单克隆抗体
    英文别名Caspase-8 subunit p10; ALPS2B; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein; Apoptosis related cysteine peptidase; Apoptotic cysteine protease; Apoptotic protease Mch 5; Apoptotic protease Mch-5; Apoptotic protease Mch5; CAP 4; CAP4; CASP 8; CASP-8; Caspase-8; Caspase8; CASP8; CASP8_HUMAN; Caspase8; Caspase 8 apoptosis related cysteine peptidase; Caspase8; CED 3; FADD homologous ICE/CED 3 like protease; FADD Homologous ICE/CED3 Like Protease; FADD Like ICE antibody FADD-homologous ICE/CED-3-like protease; FADD-like ICE; FLICE; FLJ17672; ICE like apoptotic protease 5; ICE-like apoptotic protease 5; MACH alpha 1/2/3 protein; MACH antibody MACH beta 1/2/3/4 protein antibody MCH 5; MCH5.
    产品应用WB=1:2000-5000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Mouse (Rat)
    抗体来源Mouse
    免疫原Recombinant human Caspase 8 Protein
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein G
    克隆类型Monoclonal
    理论分子量43/57 kDa
    实际分子量43kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cell Death > Apoptosis > Apoptosis Markers > Caspases

    Cancer > Cell Death > Apoptosis > Metabolism

    Cancer > Cell Death > Necroptosis

    Cancer > Invasion/microenvironment > Apoptosis > Caspases

    Cell Biology > Apoptosis > Intracellular > Caspases etc > Caspases

    Cell Biology > Proteolysis / Ubiquitin > Proteolytic enzymes > Other proteases

    Metabolism > Pathways and Processes > Metabolism processes > Apoptosis

    亚基Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 10 kDa (p10) subunit. Interacts with FADD, CFLAR and PEA15. Isoform 9 interacts at the endoplasmic reticulum with a complex containing BCAP31, BAP29, BCL2 and/or BCL2L1. Interacts with TNFAIP8L2.
    亚细胞定位Cytoplasm.
    组织特异性Isoform 1, isoform 5 and isoform 7 are expressed in a wide variety of tissues. Highest expression in peripheral blood leukocytes, spleen, thymus and liver. Barely detectable in brain, testis and skeletal muscle.
    相似性Belongs to the peptidase C14A family.
    Contains 2 DED (death effector) domains.
    功能Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase 8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase 3 and Caspase 7, which in turn cause cell collapse.

     

    应用推荐稀释比例
    {WB}{1:2000-5000}

     

    产品细节图片1
    Sample:
    Hela(Human) Cell Lysate at 30 ug
    Jurkat(Human) Cell Lysate at 30 ug
    Molt-4(Human) Cell Lysate at 30 ug
    K562(Human) Cell Lysate at 30 ug
    Primary: Anti-Caspase 8 (bsm-33190M) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 41'43'55 kD
    Observed band size: 43 kD
    产品细节图片2
    Sample:
    _x000D_ Stomach(Mouse) Lysate at 40 ug
    _x000D_ Spleen(Mouse) Lysate at 40 ug
    _x000D_ Lymph node(Mouse) Lysate at 40 ug
    _x000D_ Urinary bladder(Mouse) Lysate at 40 ug
    _x000D_ Primary: Anti-Caspase 8 (bsm-33190M) at 1/1000 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 41'43'55 kD
    _x000D_ Observed band size: 55'53D
    _x000D_
    产品细节图片3
    Sample:
    _x000D_ 293T-UV(Human) Cell Lysate at 30 ug
    _x000D_ U251-UV(Human) Cell Lysate at 30 ug
    _x000D_ Primary: Anti-Caspase 8 (bsm-33190M) at 1/4000 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
    _x000D_ Predicted band size: 41’43’55 kD
    _x000D_ Observed band size: 43 kD
    _x000D_

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    CASP8 | Caspase-8 Mouse mAb(bsm-33190M)-50ul/100ul/200ul/200ug
    ￥1180 - 5600