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- bs-20404R
- 2026年10月13日
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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-20404R |
| 英文名称 | Alx1 Rabbit pAb |
| 中文名称 | 软骨蛋白1抗体 |
| 英文别名 | ALX homeobox 1; ALX homeobox protein 1; ALX1; ALX1_HUMAN; CART 1; CART-1; CART1; Cartilage homeoprotein 1. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse, Rat (Dog, Cow, Horse, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Alx1 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 37 kDa |
| 浓度 | 1mg/ml |
| 储存液 | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| 研究领域 | Developmental Biology > Embryogenesis > Morphogens Developmental Biology > Organogenesis > Skeletal development > Bone Epigenetics and Nuclear Signaling > Transcription > Domain Families > Developmental Families Stem Cells > Mesenchymal Stem Cells > Chondrogenesis |
| 亚基 | Interacts (via homeobox domain) with EP300. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Cartilage and cervix tissue. |
| 翻译后修饰 | Acetylated at Lys-131 by EP300, leading to increased interaction with EP300 and enhances transcriptional activation activity. |
| 相似性 | Belongs to the paired homeobox family._x000D_
Contains 1 homeobox DNA-binding domain. |
| 功能 | Transcriptional activator that acts at a palindromic recognition sequence to enhance the activity of the SV40 and TK promoters. Functions as a repressor with the prolactin promoter in vivo. May play a role in chondrocyte differentiation and may also influence cervix development. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The specific function of this gene has yet to be determined in humans; however, in rodents, it is necessary for survival of the forebrain mesenchyme and may also be involved in development of the cervix. Mutations in the mouse gene lead to neural tube defects such as acrania and meroanencephaly. [provided by RefSeq, Jul 2008]. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
Paraformaldehyde-fixed, paraffin embedded (human cervical); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Alx1) Polyclonal Antibody, Unconjugated (bs-20404R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
25 ug total protein per lane of various lysates (see on figure) probed with Alx1 polyclonal antibody, unconjugated (bs-20404R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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文献和实验该产品被引用文献
[IF=1.3] Jia Yulin. et al. Correlation between CT spectral quantitative parameters and expression levels of HIF-1α and ALX1 in non-small cell lung cancer. MEDICINE. 2024 Nov;103(48):e40508 IHC Human
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ALX1 | CART1 Rabbit pAb(bs-20404R)-50ul/100ul/200ul
￥1180 - 2800
