Sample:
A431(Human) Cell Lysate at 30 ug
Primary: Anti-HMW Cytokeratin (bs-18058R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 51 kD
Observed band size: 51 kD
- ￥1180 - 2800
- Bioss
- bs-18058R
- 2025年10月16日
- 产品信息以Bioss网站为准
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产品信息以Bioss网站为准
- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-18058R |
| 英文名称 | HMW Cytokeratin Rabbit pAb |
| 中文名称 | 高分子量细胞角蛋白抗体 |
| 英文别名 | CK 13; CK 14; CK 15; CK 16; CK13; CK14; CK15; CK16; Cytokeratin 13; Cytokeratin 14; Cytokeratin 15; Cytokeratin 16; EBS3; EBS4; K13; K14; K15; K16; K1CO; K1CP; Keratin 13; Keratin 14(epidermolysis bullosa simplex, Dowling-Meara, Koebner); Keratin 14; Keratin 15; Keratin 15, basic; Keratin 15, beta; Keratin 16(focal non epidermolytic palmoplantar keratoderma); Keratin 16; Keratin, type I cytoskeletal 13; Keratin, type I cytoskeletal 16; KRT13; KRT14; KRT15; KRT16; KRT16A; KRTB; NEPPK; NFJ; Type I cytoskeletal 15. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat, Dog, Horse) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human HMW Cytokeratin |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 51 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Intermediate Filaments > Class I > Cytokeratins |
| 亚基 | Heterotetramer of two type I and two type II keratins. keratin-14 associates with keratin-5. Interacts with TRADD and with keratin filaments. Associates with other type I keratins. |
| 亚细胞定位 | Cytoplasm. Nucleus. Note=Expressed in both as a filamentous pattern. |
| 组织特异性 | Detected in the basal layer, lowered within the more apically located layers specifically in the stratum spinosum, stratum granulosum but is not detected in stratum corneum. Strongly expressed in the outer root sheath of anagen follicles but not in the germinative matrix, inner root sheath or hair. Found in keratinocytes surrounding the club hair during telogen. |
| 翻译后修饰 | A disulfide bond is formed between rather than within filaments and promotes the formation of a keratin filament cage around the nucleus. |
| 相似性 | Belongs to the intermediate filament family. |
| 功能 | The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq]. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验相关实验
Nucleic Acid Programmable Protein Arrays: Versatile Tools for Array‐Based Functional Protein Studies
.g., Sigma) 50 mg/ml bis‐sulfosuccinimdylsuberate (BS3 ;Pierce, cat. no. PI 21580) in dimethylsulfoxide (DMSO) 5 mg/ml
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HMW Cytokeratin Rabbit pAb(bs-18058R)-50ul/100ul/200ul
￥1180 - 2800
