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- 2025年10月16日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-1264R |
| 英文名称 | RSV G Rabbit pAb |
| 中文名称 | 呼吸道合胞病毒G抗体 |
| 英文别名 | RS virus; RSV; GLYC_HRSVA; Major surface glycoprotein G; Attachment glycoprotein G; Membrane-bound glycoprotein; mG; G. |
| 中文别名 | 呼吸道合胞病毒主要表面糖蛋白G; |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | HRSVA |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from HRSVA |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 33 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚基 | Homooligomer. Interacts (via N-terminus) with protein M. Interacts with protein F; this interaction occurs on the surface of infected cells. Interacts with protein SH. Interacts with host CX3CR1; this interaction modulates host immune response. |
| 亚细胞定位 | Virion membrane. Host cell surface. Isoform Secreted glycoprotein G: Secreted. |
| 翻译后修饰 | May carry 40-80 separate O-linked carbohydrate chains distributed among the 91 serine and threonine residues. Palmitoylated. |
| 相似性 | Belongs to the pneumoviruses glycoprotein G family. |
| 功能 | Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities.
Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Respiratory syncytial virus (RSV) is a major cause of respiratory illness in young children. RSV infection produces a variety of signs and symptoms involving different areas of the respiratory tract, from the nose to the lungs. RSV is a negative sense, enveloped RNA virus. The virion is variable in shape and size with average diameter of between 120 and 300 nm. The 63 kD RSV fusion protein of the RSS 2 strain (subtype A) directs fusion of viral and cellular membranes, results in viral penetration, and can direct fusion of infected cells with adjoining cells, resulting in the formation of syncytia or multi nucleated giant cells. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验[IF={{ 6.377 }}] {Pei Dai. et al. The dispersion and utilization of lipid droplets mediates respiratory syncytial virus-induced airway hyperresponsiveness. 2021 Aug 12} {IF} {Mouse}
[IF={{ 5.758 }}] {Dai Pei. et al. The antiviral efficacies of small-molecule inhibitors against respiratory syncytial virus based on the F protein. J ANTIMICROB CHEMOTH. 2022 Nov;:} {IF} {Human}
[IF={{ 5.168 }}] {Dan Liu. et al. miR-34b/c-5p/CXCL10 Axis Induced by RSV Infection Mediates a Mechanism of Airway Hyperresponsive Diseases. BIOLOGY-BASEL. 2023 Feb;12(2):317} {IF} {Mouse}
[IF={{ 4.6 }}] {Ying Han. et al. Autophagy-to-Apoptosis Conversion Mediated by GIMAP7 Exhibit Anti-RSV Action. J MED VIROL. 2025 Jul;97(8):e70520} {IF} {Mouse}
[IF={{ 4.4 }}] {Pinglang Ruan. et al. The in vitro and in vivo antiviral effects of IGF1R inhibitors against respiratory syncytial virus infection. J BIOMOL STRUCT DYN. 2024 Feb 01} {IF} {Mouse,Human}
, Algermissen, B. et al. 3. Purification of rabbit liver aldehyde oxidase by affinity chromatography on benzamidine Sepharose 6B. J. Chromatogr. (1989), 475 363-72, Stell, J. G. P. et al. 4. The Crystal Structure of a T Cell Receptor in Complex
【资源】全面归类网址：毕赤酵母表达各种来源蛋白（细菌，真菌，植物，人类等）
human leukemia inhibitory factorS, 100 mg/L, α-MF[179]Rabbit plasma cholesteryl ester transfer proteinS, PHO1[180]Rabbit testicular angiotensin converting enzymeS, PHO1, native[181]Rabbit tissue factor (thromboplastin)I, 92 mg/g wet cell paste, active519
Nucleic Acid Programmable Protein Arrays: Versatile Tools for Array‐Based Functional Protein Studies
.g., Sigma) 50 mg/ml bis‐sulfosuccinimdylsuberate (BS3 ;Pierce, cat. no. PI 21580) in dimethylsulfoxide (DMSO) 5 mg/ml
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