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- 2026年10月13日
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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-16185R |
| 英文名称 | FRZB/FRP-3 Rabbit pAb |
| 中文名称 | FRZB蛋白抗体 |
| 英文别名 | FIZ; FRE; Frezzled; Fritz; Frizzled-related protein 1; FRP; FrzB 1; FRZB; MYOZ3_HUMAN; FRZB1; OTTMUSP00000014350; RP23-33L19.1; Secreted frizzled related protein 3 [Precursor]; Secreted frizzled related sequence protein 3; sFRP 3; SFRP. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, ICC/IF=1:100-500, IF=1:100-500, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | (Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human FRZB/FRP-3 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 27 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > Structures > Bone Stem Cells > Signaling Pathways > Wnt > Secreted |
| 亚细胞定位 | Secreted |
| 组织特异性 | Expressed specifically in skeletal muscle. Not detected in heart. |
| 相似性 | Belongs to the myozenin family. |
| 功能 | SFRP3/FRZB appears to be involved in limb skeletogenesis by regulating chondrocyte maturation and long bone development. Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. Antagonist of Wnt8 signaling. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {ICC/IF} | {1:100-500} |
| {IF} | {1:100-500} |
| {ELISA} | {1:5000-10000} |
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文献和实验[IF=4.2] Zhengyu Lin. et al. Unraveling the Role of PTGIR in Atrial Fibrillation: Insights From Single-Cell Sequencing and Mendelian Randomization. FASEB J. 2025 Nov;39(22):e71200 WB Rat
v468.Chapter 3 分泌型跨膜相关蛋白提纯及Wnt抑制活性
a convenient source of these proteins for biological studies. Yields of protein vary; screening of clonallines for high expression is usually worthwhile. Heparin affinity chromatography is an easy step thatprovides a major enrichment, particularly for sFRP
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