Positive control: RSC96
Isotype Control Antibody: Rabbit IgG ;
Secondary Antibody: Goat anti-rabbit IgG-FITC,
Dilution: 1:100 in 1 X PBS containing 0.5% BSA ;
Primary Antibody Dilution: 3μg in 100 μL1X PBS containing 0.5% BSA.
- ￥1180 - 2800
- Bioss
- bs-11532R
- 2025年10月24日
- 产品信息以Bioss网站为准
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- 应用范围：
产品信息以Bioss网站为准
- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-11532R |
| 英文名称 | PTPRN Rabbit pAb |
| 中文名称 | 蛋白酪氨酸磷酸酶样N前体蛋白抗体 |
| 英文别名 | PTPIA2; RPTPN; TPIA2; CA 512; IA 2; IA 2/PTP; IA2; IA2/PTP; ICA 3; ICA 512; ICA3; ICA512; Islet cell antigen 2; Islet cell antigen 512; Islet cell autoantigen 3; Protein tyrosine phosphatase like N; Protein tyrosine phosphatase like N precursor; Protein tyrosine phosphatase receptor type N; PTP IA 2; PTP IA-2; PTP IA2; PTPIA 2; PTPN; Ptprn; PTPRN protein; PTPRN_HUMAN; R PTP N; R-PTP-N; Receptor type tyrosine protein phosphatase like N; Receptor-type tyrosine-protein phosphatase-like N. |
| 产品应用 | Flow-Cyt=3μg/Test Not yet tested in other applications. |
| 交叉反应 | Rat (Human, Mouse, Pig, Cow, Sheep) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human TPIA2 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 102 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Neuroscience > Neurology process > Metabolism Signal Transduction > Protein Phosphorylation > Tyrosine Phosphatases |
| 亚基 | Interacts with phosphorylated SNTB2, protecting it from protein cleavage by CAPN1. Dephosphorylation of SNTB2 upon insulin stimulation disrupts the interaction and results in its cleavage. |
| 亚细胞定位 | Membrane. Neuroendocrine secretory granules. |
| 组织特异性 | Expression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary. |
| 翻译后修饰 | Appears to undergo multiple proteolytic cleavage at consecutive basic residues. |
| 相似性 | Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. Contains 1 tyrosine-protein phosphatase domain. |
| 功能 | Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010] |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {3μg/Test} |
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PTPRN Rabbit pAb(bs-11532R)-50ul/100ul/200ul
￥1180 - 2800
