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- 2025年10月16日
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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-8525R |
| 英文名称 | DNA Polymerase beta Rabbit pAb |
| 中文名称 | DNA聚合酶β抗体 |
| 英文别名 | DNA Polymerase beta; DNA pol beta; DNA directed DNA polymerase beta; DNA polymerase beta; DNA polymerase beta subunit; DPOLB_HUMAN; MGC125976; Pol B; Pol beta; PolB; Polymerase(DNA directed) beta. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | (Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human DNA Polymerase beta |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 37 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > DNA Damage & Repair > Base Excision Repair Epigenetics and Nuclear Signaling > DNA / RNA > DNA Synthesis > DNA Polymerases |
| 亚细胞定位 | Monomer. Interacts with APEX1, HUWE1/ARF-BP1, STUB1/CHIP and USP47. |
| 翻译后修饰 | Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity. |
| 相似性 | Belongs to the DNA polymerase type-X family. |
| 功能 | Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases (1). In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches (2). These exonucleases include the family of DNA polymerases (3). DNA pol α, β, ∂, and e are involved in DNA replication and repair (4). DNA pol ∂ and DNA pol e are multisubunit enzymes, with DNA pol ∂ consisting of two subunits p125, which interacts with the sliding DNA clamp protein PCNA, and p50 (5). The nuclear-encoded DNA pol © is the only DNA polymerase required for the replication of the mitochondrial DNA (6). DNA pol Ω is ubiquitously expressed in various tissues and mediates the cellular mechanism of damage-induced mutagenesis (7). DNA pol œ is a DNA polymerase-helicase that binds ATP and is involved in the repair of interstrand crosslinks (8). |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
| {ELISA} | {1:5000-10000} |
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文献和实验相关专题 重组DNA技术工具酶 核糖核酸聚合酶(RNA polymerase) 催化RNA合成的酶。主要指DNA指导的RNA聚合酶，即以DNA为模板，以4种核苷三磷酸(ATP，GTP，CTP和UTP)为底物，从5′到3′合成RNA的酶。其催化方式与DNA聚合酶 相似，但不具备有校正作用的外切核酸酶活性，聚合反应也不需引物。 对大肠杆菌 RNA聚合酶了解得最多。这种酶含有多个亚基，全
相关专题 重组DNA技术工具酶 核糖核酸聚合酶(RNA polymerase) 催化RNA合成的酶。主要指DNA指导的RNA聚合酶，即以DNA为模板，以4种核苷三磷酸(ATP，GTP，CTP和UTP)为底物，从5′到3′合成RNA的酶。其催化方式与DNA聚合酶 相似，但不具备有校正作用的外切核酸酶活性，聚合反应也不需引物。 对大肠杆菌 RNA聚合酶了解得最多。这种酶含有多个亚基，全
Hapten Labeling of Nucleic Acids for Immuno-Polymerase Chain Reaction Applications
A method for the ultrasensitive protein detection in the range of 0.01 to 10,000 amol of the model antibody anti-mouse-IgG from rabbit is described, using a combination of Immunopolymerase chain reaction (PCR) and PCR-enzyme-linked
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