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Frequently Asked QuestionsFrequently Asked Questions are available for this Product.Biochem/physiol Actions强效的铂基抗肿瘤剂。与 DNA 二核苷酸 d(pGpG) 形成细胞毒性加合物，诱导链内交联。Potent chemoimmunotherapeutic drug; stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin-treated macrophages show increased antigen presentation function in vitro. Treatment increased cellular NF-κB content and translocation in macrophages. Cisplatin effects are regulated by kinases, phosphatases, and Ca2+/calmodulin. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand crosslinks.包装1 g in glass bottle25, 100, 250 mg in glass bottleFeatures and BenefitsThis compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.This compound was developed by Corden. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.法律信息LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
性质
Related CategoriesAntibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Approved Therapeutics/Drug Candidates,
更多...InChI Key LXZZYRPGZAFOLE-UHFFFAOYSA-Lform crystallinecolor yellowmp 270 °C(lit.)Mode of action DNA synthesis | interferesoriginator Corden