- ￥498 - 2798
- TargetMol
- USA
- T2491
- 2025年07月02日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20°C
- 保质期：
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -2511℃ for several months.
- 英文名：
AZ5104
- 库存：
详询
- 供应商：
详询
- CAS号：
1421373-98-9
- 规格：
5mg/10mg/50mg/1ml/10mM
| 规格： | 5mg | 产品价格： | ￥498.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥998.0 |
| 规格： | 50mg | 产品价格： | ￥2798.0 |
| 规格： | 1ml/10mM | 产品价格： | ￥685.0 |
ID：T2491
PURITY：99%+
Formula：C27H31N7O2
MolWt：485.58
Appearance：淡黄色粉末
Solubility：G4200 mM in DMSO
Bioactivity：AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1.
Status：
Pathways：Tyrosine Kinase/Adaptors
Target：EGFR inhibitor; IGF-1R inhibitor; TGF-beta/Smad inhibitor
Receptor：EGFR;ErbB4;ACK1;BLK;BRK;MNK2;IGF-1R; ALK;TEC;FES;Ins R
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文献和实验,Gregory B,Hover A,Chen MY,Luci J,Joo SJ,Handwerker D,Liang J,Boyd R,Hunicke- Smith S,Simpson ZB,Caven T, Sochat V,Shine JM,Gordon E,Snyder AZ,Adeyemo B,Petersen SE,Glahn D, McKay DR,Curran JE,Göring HHH,Carless MA,Blangero J,Frick L,Marcotte E, Mumford JA
Protocols for Studying Antizyme Expression and Function
Antizyme (AZ) is a key molecule in feedback regulation of cellular polyamines. It is induced by polyamines through stimulation of ribosomal frameshifting during its translation. In mammals, AZ is diverged into three paralogs, AZ1–3. Tissue
Identification, Assay, and Functional Analysis of the Antizyme Inhibitor Family
essential cellular functions, their intracellular concentration is tightly regulated via a unique autoregulatory circuit that responds to the intracellular concentration of polyamines. In the heart of this circuit is a small protein called antizyme (Az
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