For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -1822℃ for several months.
英文名:
LDK378(Ceritinib)
库存:
详询
供应商:
详询
CAS号:
1032900-25-6
规格:
5mg/10mg/50mg/100mg/1ml/10mM
规格:
5mg
产品价格:
¥707.0
规格:
10mg
产品价格:
¥1010.0
规格:
50mg
产品价格:
¥2727.0
规格:
100mg
产品价格:
¥3737.0
规格:
1ml/10mM
产品价格:
¥685.0
ID:T1791
PURITY:1
Formula:C28H36ClN5O3S
MolWt:558.14
Appearance:白色粉末
Solubility:G4DMSO > 10mM
Bioactivity:Ceritinib is an orally available inhibitor of the receptor tyrosine kinase activity of anaplastic lymphoma kinase (ALK) with antineoplastic activity. Upon administration, ceritinib binds to and inhibits wild-type ALK kinase, ALK fusion proteins and ALK point mutation variants. Inhibition of ALK leads to both the disruption of ALK-mediated signaling and the inhibition of cell growth in ALK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a variety of tumor cell types.