- ￥428 - 1998
- TargetMol
- USA
- T2423
- 2025年07月14日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20°C
- 保质期：
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -2444℃ for several months.
- 英文名：
P7C3-A20
- 库存：
详询
- 供应商：
详询
- CAS号：
1235481-90-9
- 规格：
2mg/5mg/10mg/25mg/1ml/10mM
| 规格： | 2mg | 产品价格： | ￥428.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥628.0 |
| 规格： | 10mg | 产品价格： | ￥1088.0 |
| 规格： | 25mg | 产品价格： | ￥1998.0 |
| 规格： | 1ml/10mM | 产品价格： | ￥915.0 |
ID：T2423
PURITY：97%+
Formula：C22H19Br2FN2O
MolWt：506.2
Appearance：黄色粘稠状固体
Solubility：G410 mM in DMSO
Bioactivity：P7C3 is a drug related to latrepirdine (dimebon), which has neuroprotective and proneurogenic effects, and may be potentially useful for the treatment of Alzheimer's disease and similar neurodegenerative disorders. The precise mechanism of action through which these effects are exerted remains unclear as of 2010, but the pharmacological effects of P7C3 in vitro resemble those of endogenous proneurogenic peptides such as fibroblast growth factor 1, and the proneurogenic activity of P7C3 was around thirty times that of dimebon when they were compared side by side in mice. P7C3 was chosen for further animal studies on the basis of favourable pharmacokinetic factors, such as its high oral bioavailability and long duration of action, but several other related compounds showed similar activity such as the more potent fluorinated analogue P7C3A20 which is up to ten times stronger again, and the methoxy analogue P7C3-OMe, for which it was determined that the (R) enantiomer is the active form.
Status：
Pathways：Neuroscience
Target：Others
Receptor：Others
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文献和实验Yeast Two-Hybrid Screening for Proteins Interacting With the Anti-Apoptotic Protein A20
by the detection of binding partners for the zinc finger protein A20. The latter is an inducible cellular inhibitor of tumor necrosis factor (TNF)-induced apoptosis and nuclear factor (NF)-κB-dependent gene expression. Yeast two-hybrid screening with A20 as bait
Cellular Expression of A20 and ABIN-3 in Response to Toll-Like Receptor-4 Stimulation
levels of the NF-κB inhibitory proteins A20 and ABIN-3 in response to TLR4 stimulation by lipopolysaccharide (LPS).
factor 2 (TRAF-2) that recruits NF-kB-inducible kinase (NIK). Both IKK1 and IKK2 have canonical sequences that can be phosphorylated by the MAP kinase NIK/MEKK1 and both kinases can independently phosphorylate IkBa or IkBb. TRAF-2 also interacts with A20
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