- ￥348 - 3465
- TargetMol
- USA
- T2689
- 2025年07月15日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20°C
- 保质期：
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -2707℃ for several months.
- 英文名：
AZ 3146
- 库存：
详询
- 供应商：
详询
- CAS号：
1124329-14-1
- 规格：
2mg/5mg/10mg/25mg/50mg/1ml/10mM
| 规格： | 2mg | 产品价格： | ￥348.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥658.0 |
| 规格： | 10mg | 产品价格： | ￥1010.0 |
| 规格： | 25mg | 产品价格： | ￥2233.0 |
| 规格： | 50mg | 产品价格： | ￥3465.0 |
| 规格： | 1ml/10mM | 产品价格： | ￥1212.0 |
ID：T2689
PURITY：1
Formula：C24H32N6O3
MolWt：452.55
Appearance：白色粉末
Solubility：G460 mM in DMSO
Bioactivity：AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit.
Status：
Pathways：Cell Cycle/Checkpoint
Target：Kinesin inhibitor
Receptor：Mps1
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文献和实验,Gregory B,Hover A,Chen MY,Luci J,Joo SJ,Handwerker D,Liang J,Boyd R,Hunicke- Smith S,Simpson ZB,Caven T, Sochat V,Shine JM,Gordon E,Snyder AZ,Adeyemo B,Petersen SE,Glahn D, McKay DR,Curran JE,Göring HHH,Carless MA,Blangero J,Frick L,Marcotte E, Mumford JA
Protocols for Studying Antizyme Expression and Function
Antizyme (AZ) is a key molecule in feedback regulation of cellular polyamines. It is induced by polyamines through stimulation of ribosomal frameshifting during its translation. In mammals, AZ is diverged into three paralogs, AZ1–3. Tissue
Identification, Assay, and Functional Analysis of the Antizyme Inhibitor Family
essential cellular functions, their intracellular concentration is tightly regulated via a unique autoregulatory circuit that responds to the intracellular concentration of polyamines. In the heart of this circuit is a small protein called antizyme (Az
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