Human Programmed Cell Death Pr

Induction of Programmed Cell Death with an Antisense Bcl-2 Oligonucleotide

(3 ,4 ). Therefore, genetic manipulation of PCD regulatory genes may restore the altered homeostasis in these cells and permit these genetically damaged cells to enter PCD.A known regulator of the PCD pathway is Bcl-2, a protein capable of suppressing cell death

Relationship of EGFR Signal-Transduction Modulation by Tyrosine Kinase Inhibitors to Chemosensitivity and Programmed Cell Death in Lung Cancer Cell Li

has been reported in a wide range of human malignancies, including non-small cell lung cancer (NSCLC) (4 -6) . One early consequence of the binding of EGFR ligands (EGF or transforming growth factor-α [TGF-α]) to EGFR is the induction of receptor dimerization

Procedures for the Quantitative Protein Determination of Urokinase and Its Inhibitor, PAI-1, in Human Breast Cancer Tissue Extracts by ELISA

) or early death. The serine protease uPA, in concert with its inhibitor PAI-1, promotes tumor cell adhesion, migration, and proliferation, as well as extracellular matrix degradation and, thus, facilitates tumor cell invasion and metastasis. The various