产品封面图

EGFR Gene Mutation PCR Array

收藏
  • 询价
  • 2026年02月16日
    avatar
    上海杏园瑞民生物工程有限公司
    未合作商家

    相关产品推荐更多 >

    万千商家帮你免费找货

    0 人在求购买到急需产品
    同类优质商家
    16 年钻石会员
    上海英拜生物科技有限公司
    业务范围：
    技术服务,论文服务
    • 详细信息
    • 文献和实验
    • 技术资料
    The Human EGFR Gene qBiomarker Somatic Mutation PCR Array allows the detection of 44 unique mutations in the human EGFR gene. EGFR, a proto-oncogene and a receptor tyrosine kinase, activates MAP kinase, AKT, and JNK signaling pathways to regulate cellular migration, adhesion, and proliferation. Previous scientific reports have shown a strong association between mutations in the EGFR gene and lung cancer as well as glioblastoma multiforme. The EGFR mutations found in cancer samples include missense point mutations and inactivating nonsense mutations in the P-loop, activation loop, and kinase domains. The DNA sequence mutation assays in the array detect the most frequent mutations in EGFR compiled from over 12,250 reported cancer sample sequences. Each mutation assay is bench-tested for the sensitive detection of a low percentage of mutation-containing DNA in a background of wild-type genomic DNA. The 96-well format of this array profiles the mutation status of 2 samples, while the 384-well array format profiles 8 samples, and each set of plates includes qPCR mastermix. Using real-time PCR, research studies can easily and reliably detect a panel of mutations in the EGFR gene with this array.
    Nucleotide Change Amino Acid Change Mutation Frequency
    c.2573T>G p.L858R 0.0976
    c.2235_2249del15 p.E746_A750del 0.0423
    c.2236_2250del15 p.E746_A750del 0.0236
    c.2240_2257del18 p.L747_P753>S 0.0088
    c.2369C>T p.T790M 0.0061
    c.2239_2248TTAAGAGAAG>C p.L747_A750>P 0.0057
    c.2237_2255>T p.E746_S752>V 0.0035
    c.2240_2254del15 p.L747_T751del 0.0033
    c.2582T>A p.L861Q 0.0027
    c.2239_2256del18 p.L747_S752del 0.0021
    c.2155G>A p.G719S 0.0019
    c.2303G>T p.S768I 0.0018
    c.2156G>C p.G719A 0.0018
    c.866C>T p.A289V 0.0016
    c.2239_2253del15 p.L747_T751del 0.0015
    c.2239_2251>C p.L747_T751>P 0.0015
    c.2239_2247del9 p.L747_E749del 0.0014
    c.2237_2251del15 p.E746_T751>A 0.0014
    c.2155G>T p.G719C 0.0013
    c.2497T>G p.L833V 0.0012
    c.1793G>T p.G598V 0.0012
    c.2125G>A p.E709K 0.0008
    c.2307_2308insGCCAGCGTG p.V769_D770insASV 0.0007
    c.2126A>C p.E709A 0.0007
    c.2240_2251del12 p.L747_T751>S 0.0006
    c.2239_2258>CA p.L747_P753>Q 0.0006
    c.323G>A p.R108K 0.0005
    c.89_889del801 p.V30_R297>G 0.0004
    c.2203G>A p.G735S 0.0003
    c.2238_2248>GC p.L747_A750>P 0.0003
    c.2126A>G p.E709G 0.0003
    c.2238_2255del18 p.E746_S752>D 0.0003
    c.787A>C p.T263P 0.0003
    c.865G>A p.A289T 0.0002
    c.2126A>T p.E709V 0.0002
    c.866C>A p.A289D 0.0002
    c.2237_2252>T p.E746_T751>V 0.0002
    c.2572C>A p.L858M 0.0002
    c.2310_2311insGGT p.D770_N771insG 0.0002
    c.2248G>C p.A750P 0.0002
    c.2429G>A p.G810D 0.0002
    c.2156G>A p.G719D 0.0002
    c.2239_2256>CAA p.L747_S752>Q 0.0002
    c.2193G>A p.W731* 0.0002

    风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。

    图标文献和实验
    相关实验

    • Complete Array of HOX Gene Expression by RQ-PCR

      , they exhibit a high degree of sequence similarity, particularly in the homeobox domain. HOX gene expression, the HOXOME , can be quantified by real-time quantitative PCR (RQ-PCR) using carefully selected reagents. In practice, an RQ-PCR platform based on Taqman

    • Gene Array Technology and the Study of Platelets and Megakaryocytes

      via base pairing. The invention of reverse transcription polymerase chain reaction (RT-PCR) (4 ) greatly improved the sensitivity of gene expression analysis, allowing for the detection of very low abundant transcripts semiquantitatively and, more recently

    • Genotyping of Mutation in the Beta-Globin Gene Using DNA Microarrays

      detection methods. The demonstrated colorimetric detection of mutations has an expected error frequency of about 5 � 10−7 per mutation or better. Given this low error frequency, an array diagnosing 100 different mutations would misclassify about 1 patient

    查看更多相关实验 >
    图标技术资料

    暂无技术资料 索取技术资料

    同类产品报价

    产品名称
    产品价格
    公司名称
    报价日期
    KIT Gene Mutation PCR Array
    询价
    上海杏园瑞民生物工程有限公司
    2025年07月15日询价
    肝癌 Mutation PCR Array Liver Cancer Mutation PCR Array
    询价
    上海英拜生物科技有限公司
    2026年04月21日询价
    表达谱芯片｜伯豪生物表达谱芯片
    ￥5000
    上海伯豪生物技术有限公司
    2026年04月22日询价
    Patharray™服务--疾病关键基因机制研究利器
    询价
    上海吉凯基因医学科技股份有限公司
    2026年04月24日询价
    肝癌51点组织芯片HLiv-D051Bch-01
    询价
    上海芯超生物科技有限公司
    2026年04月18日询价
    EGFR Gene Mutation PCR Array
    询价