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Antigen Uptake: CD44, CDC42, ICAM1, ICAM2, RAC1, TAP2 (ABCB3).
Antigen Presentation: CCL19, CD1A, CD1B, CD1C, CD1D, CD209, CD28, CD4, CD40 (TNFRSF5), CD40LG (TNFSF5), CD74, CD80, CD86, CD8A, HLA-A, HLA-DMA, HLA-DPA1, TAPBP, THBS1.
Dendritic Cell Chemotaxis: CCL19, CCL5 (RANTES), CCR1, CCR2, CCR5, CXCR1 (IL8RA), CXCR4.
Dendritic Cell Differentiation: CSF2 (GM-CSF), LYN, RELB, TGFB1.
Cytokines: CCL11 (Eotaxin), CCL13 (MCP-4), CCL16 (HCC4), CCL19, CCL2 (MCP-1), CCL3 (MIP- 1A), CCL5 (RANTES), CCL7 (MCP-3), CCL8 (MCP-2), CSF2 (GM-CSF), CXCL1, CXCL10 (INP10), CXCL12 (SDF1), CXCL2, FLT3LG, IFNG, IL10, IL12A, IL12B, IL16, IL2, IL6, IL8, MIF, TNF, TNFSF11.
Cytokine Receptors: CCR1, CCR2, CCR3, CCR5, CSF1R, CXCR1 (IL8RA), CXCR4, FLT3, ERBB2 (HER2).
Other Cell Surface Receptors: CD2, CD40 (TNFRSF5), FCER1A, FCER2, FCGR1A, LRP1, TLR1, TLR2, TLR7, TLR9, VCAM1.
Signal Transduction: CDKN1A (p21CIP1/WAF1), CEBPA, CLEC4C, FAS (TNFRSF6), IRF7, IRF8, ITGAM, ITGB2, LYN, NFKB1, PTPRC, RELA, RELB, STAT3, TGFB1.
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文献和实验The Purification of Large Numbers of Antigen Presenting Dendritic Cells from Mouse Spleen
may instead be separated using a combination of fluorescent antibody labeling and anti-fluorochrome magnetic beads. Careful segregation of these functionally distinct subpopulations of DC will enable a thorough examination of their antigen processing and presenting
Dendritic cells (DC) are widely considered to be the major antigen-presenting cell (APC) type in immune responses. These cells are obtained from adherent cells or are purified CD14+ monocytes from peripheral blood mononuclear cells (PBMC
Antigen-Pulsed Dendritic Cell Approach to Melanoma
Dendritic cells (DCs) are potent antigen-presenting cells (1 ) with wide tissue distribution. They are classified based primarily on their localization: as Langerhans cells when present in the epidermis and as dermal DCs
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