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文献和实验Nature:癌症疫苗新突破!调动 T 细胞与 NK 细胞的双重攻击,全面杀灭癌细胞
症研究所、哈佛医学院免疫学系等单位的研究人员在 Nature 期刊发表了题为 A vaccine targeting resistant tumours by dual T cell plus NK cell attack 的文章,报道了他们开发了一种以肿瘤免疫逃逸机制为靶点的新型癌症疫苗,可以诱导不同的 T 细胞和 NK 细胞进行协同攻击。 该疫苗诱导产生的抗体通过抑制蛋白水解而增加肿瘤细胞表面 MICA/B 蛋白的密度,以此增强树突状细胞对 T 细胞肿瘤抗原的呈递,并增强 NK 细胞的细胞
Isolation of Dendritic Cells from Rat Intestinal Lymph and Spleen
Dendritic cells (DC) are rare cells in peripheral tissues, and their isolation from tissues is fraught with problems. Thus, the proportion of DC within a tissue that is extracted is unknown, isolation procedures may select for subpopulations
Genetic Modification of Dendritic Cells Through the Directed Differentiation of Embryonic Stem Cells
Recent years have witnessed a progressive acceptance of the dual role played by dendritic cells (DC) in the initiation of immune responses and their specific attenuation through the induction of immunological tolerance
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