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文献和实验Measurement of Proton Leak and Electron Leak in Isolated Mitochondria
. In this chapter, methods are presented to measure proton and electron leak activities in isolated mitochondria. The relative strength of a modular kinetic approach to probe oxidative phosphorylation is emphasised.
Cytokine-Induced Vascular Leak Syndrome
The vascular leak syndrome (VLS) is a major dose-limiting toxicity of cytokine therapy. VLS is characterized by an increase in vascular permeability resulting in tissue edema and, ultimately, multiple organ failure. The most frequent clinical
Measurement of Mitochondrial Membrane Potential and Proton Leak
membrane potential causes uncoupling of the electron transport through the respiratory chain and the phosphorylation reaction for ATP synthesis (proton leak). Proton leak functions as a regulator of mitochondrial reactive oxygen species (ROS) production
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