Vincamine 是从马达加斯加长春花中提取的一种单萜类吲

Vincamine is a monoterpenoid indole alkaloid extracted from the Madagascar periwinkle. Vincamine is a peripheral vasodilator and exerts a selective vasoregulator action on the brain microcapilar circulation^[1]. Vincamine is a GPR40 agonist and acts as a β-cell protector by ameliorating β-cell dysfunction and promoting glucose-stimulated insulin secretion (GSIS). Vincamine improves glucose homeostasis in vivo, and has the potential for the type 2 diabetes mellitus (T2DM) research^[2].

Vincamine (20, 40 and 80 μM; 24 hours) exerts a significant, concentration-dependent protective effect in LPS-treated human corneal epithelial cells (HCECs) cells^[1].
Vincamine (20, 40 and 80 μM; 24 hours) significantly reduces ROS level in a dose-dependent manner in LPS-treated human corneal epithelial cells (HCECs)cells. Additionally, after Vincamine administration, the levels of MDA is also significantly reduced while the levels of T-AOC, and SOD are increased in a dose-dependent manner^[1].
Vincamine (20, 40 and 80 μM; 24 hours) rescues TrxR activity in a dose-dependent manner in HCECs. However, the intracellular activities of Trx, GR and GPx are neither inhibited nor activated by both LPS and Vincaminer^[1].
Vincamine could activate GPR40 (EC₅₀=6.28 µM) with DHA (GPR40 ligand) as a positive control (EC₅₀=3.85 µM) in hGPR40-CHO cells^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Vincamine (intraperitoneal injection; 15 and 30 mg/kg/day; 6 weeks) improves glucose tolerance in type 2 diabetic model mice. It effectively lowers the levels of fasting blood glucose and glycated hemoglobin. At the same time, it ameliorates oral glucose tolerance and elevated glucose-induced plasma insulin concentration without influence on basal insulin secretion in vivo^[2].<.br>

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

354.44

C₂₁H₂₆N₂O₃

1617-90-9

长春胺；长春花素；太司尼克酸；长春蔓胺；阿朴长春胺酸乙酯；长春花胺

• Alkaloids
• Indole Alkaloids

• Plants
• Apocynaceae
• Catharanthus roseus (L.) G. Don

Room temperature in continental US; may vary elsewhere.

DMSO : 25 mg/mL (70.53 mM; Need ultrasonic)

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• [1]. Te Du, et al. Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice. J Endocrinol. 2019 Feb 1;240(2):195-214. [Content Brief]

  [2]. Li Wu, et al. Vincamine prevents lipopolysaccharide induced inflammation and oxidative stress via thioredoxin reductase activation in human corneal epithelial cells. Am J Transl Res. 2018 Jul 15;10(7):2195-2204. eCollection [Content Brief]