手机验证
4°C
详见说明
Pyridostigmine bromide
充足
杭州昊鑫生物
101-26-8
1g
生物活性 | Pyridostigmine bromide is a parasympathomimetic and a reversible cholinesterase inhibitor. Target: AChE Pyridostigmine bromide is a parasympathomimetic and a reversible cholinesterase inhibitor. Since it is a quaternary amine, it is poorly absorbed in the gut and does not cross the blood–brain barrier, except possibly in stressful conditions. Pyridostigmine bromide inhibits acetylcholinesterase in the synaptic cleft, thus slowing down the hydrolysis of acetylcholine. It is a quaternary carbamate inhibitor of cholinesterase that does not cross the blood–brain barrier which carbamylates about 30% of peripheral cholinesterase enzyme. The carbamylated enzyme eventually regenerates by natural hydrolysis and excess ACh levels revert to normal. Pyridostigmine bromide is used to treat muscle weakness in people with myasthenia gravis and to combat the effects of curariform drug toxicity. Pyridostigmine bromide has been FDA approved for military use during combat situations as an agent to be given prior to exposure to the nerve agent Soman in order to increase survival. Used in particular during the first Gulf War, pyridostigmine bromide has been implicated as a causal factor in Gulf War syndrome. Pyridostigmine bromide sometimes is used to treat orthostatic hypotension. It may also be of benefit in chronic axonal polyneuropathy. |
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Clinical Trial |
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分子量 | 261.12 |
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Formula | C9H13BrN2O2 |
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CAS 号 | |||||||||||||||||
中文名称 | 溴化吡啶斯的明 |
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运输条件 | Room temperature in continental US; may vary elsewhere. |
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储存方式 | 4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
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溶解性数据 | In Vitro: DMSO : 50 mg/mL (191.48 mM; Need ultrasonic) H2O : 8.8 mg/mL (33.70 mM; Need ultrasonic and warming) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百 |
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