Miriplatin (SM-11355) 为有效的化疗剂，

Miriplatin  (Synonyms: SM-11355)

Miriplatin (SM-11355) 为有效的化疗剂，是烷化剂 (alkylator) 的一种。

美国medchemexpress（MCE)浙江省一级代理:杭州昊鑫生物科技股份有限公司
MCE中国是全球领先的科研化学品和生物活性化合物供应商，总部位于美国新泽西。我们的产品范围覆盖各种抑制剂、激动剂、API和化合物库。专业、高效的企业灵魂铸造了在行业的卓越地位。热情和充满活力的研发团队拥有着大量的化学和生物科学家。专注于生物活性化合物，拥有着多年的发展历程和丰富的行业经验。

生物活性    
Miriplatin (SM-11355) is a chemotherapy agent which belongs to the class of alkylating agents.

体外研究
(In Vitro)    
Miriplatin (SM-11355) suspended in LPD (miriplatin/LPD, 100 μg/mL) inhibits the growth of AH109A cells, forms platinum-DNA adducts, and induces apoptosis[2].

体内研究
(In Vivo)    
Miriplatin (SM-11355) (0.02-0.4 mg/20 μL) in lipiodol reduces tumor growth rates in a dose dependent manner in rats bearing AH109A tumor cells[1]. Miriplatin/LPD (400 μg/head) significantly reduces the growth of tumor in rats bearing AH109A cells[2].

分子量    
764.00

性状    
Solid

Formula    
C34H68N2O4Pt

CAS 号    
141977-79-9

中文名称    
米铂

运输条件    
Room temperature in continental US; may vary elsewhere.

储存方式    
Powder    -20°C    3 years
4°C    2 years
In solvent    -80°C    6 months
-20°C    1 month
溶解性数据    
In Vitro: 
AcetonE: < 1 mg/mL (ultrasonic) (insoluble; DMSO can inactivate Miriplatin's activity)

DMF : < 1 mg/mL (insoluble; DMSO can inactivate Miriplatin's activity)

H2O : < 0.1 mg/mL (insoluble; DMSO can inactivate Miriplatin's activity)

*Miriplatin is usually formulated as a suspension.

参考文献

• [1]. Kishimoto S, et al. Antitumor effects of a novel lipophilic platinum complex (SM-11355) against a slowly-growing rat hepatic tumor after intra-hepatic arterial administration. Biol Pharm Bull. 2000 Mar;23(3):344-8.  [Content Brief]

  [2]. Hanada M, et al. Intra-hepatic arterial administration with miriplatin suspended in an oily lymphographic agent inhibits the growth of tumors implanted in rat livers by inducing platinum-DNA adducts to form and massive apoptosis. Cancer Chemother Pharmaco  [Content Brief]