生物活性
Miriplatin (SM-11355) is a chemotherapy agent which belongs to the class of alkylating agents.
体外研究
(In Vitro)
Miriplatin (SM-11355) suspended in LPD (miriplatin/LPD, 100 μg/mL) inhibits the growth of AH109A cells, forms platinum-DNA adducts, and induces apoptosis[2].
体内研究
(In Vivo)
Miriplatin (SM-11355) (0.02-0.4 mg/20 μL) in lipiodol reduces tumor growth rates in a dose dependent manner in rats bearing AH109A tumor cells[1]. Miriplatin/LPD (400 μg/head) significantly reduces the growth of tumor in rats bearing AH109A cells[2].
分子量
764.00
性状
Solid
Formula
C34H68N2O4Pt
CAS 号
141977-79-9
中文名称
米铂
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro:
AcetonE: < 1 mg/mL (ultrasonic) (insoluble; DMSO can inactivate Miriplatin's activity)