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- medchemexpress(MCE)
- 美国
- HY-15841
- 2025年07月11日
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- 保存条件：
4℃
- 保质期：
详见说明
- 英文名：
CEP-37440
- 库存：
充足
- 供应商：
杭州昊鑫生物
- CAS号：
1391712-60-9
- 规格：
5mg
CEP-37440
CEP-37440 是一种口服有效的双重 FAK/ALK 抑制剂，抑制 FAK 和 ALK 的 IC50 值分别为 2.3 nM和 3.5 nM。CEP-37440 通过阻断 FAK1 (Tyr 397) 的自磷酸化激酶活性降低细胞增殖。
美国medchemexpress（MCE)浙江省一级代理:杭州昊鑫生物科技股份有限公司
MCE中国是全球领先的科研化学品和生物活性化合物供应商，总部位于美国新泽西。我们的产品范围覆盖各种抑制剂、激动剂、API和化合物库。专业、高效的企业灵魂铸造了在行业的卓越地位。热情和充满活力的研发团队拥有着大量的化学和生物科学家。专注于生物活性化合物，拥有着多年的发展历程和丰富的行业经验。
生物活性
CEP-37440 is a potent, orally active dual FAK/ALK inhibitor with IC50 values of 2.3 nM and 3.5 nM for FAK and ALK, respectively. CEP-37440 decreases the cell proliferation by blocking the autophosphorylation kinase activity of FAK1 (Tyr 397)[1][2].
IC50 & Target
IC50:2.3 nM (FAK) and 3.5 nM (ALK)[2]
体外研究(In Vitro)
CEP-37440 (0-3000 nM；0-192 h) 以剂量依赖性方式降低炎症性乳腺癌 (IBC) 细胞的增殖[1]。
CEP-37440 (1000 nM；0-120 h) 降低磷酸化 FAK1 (Tyr 397) 并在 FC-IBC02、SUM 190 和 KPL4[1] 中随时间保持其低水平。
CEP- 37440 (0-3000 nM；Sup-M2 和 Karpas-299 细胞) 以剂量依赖性方式诱导促凋亡半胱天冬酶[2]。
Cell Viability Assay[1]
Cell Line: FC-IBC02, KPL4, SUM190, MDA-IBC03 and SUM149 cells
Concentration: 0, 300, 1000, 2000 and 3000 nM
Incubation Time: 0, 24, 48, 72, 96, 120, 144, 168, and 192 hours
Result: Reduced the proliferation of three out of five IBC cell lines at low concentration. Inhibited the proliferation almost completely at 3000 nM concentration.
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