TRCP6-IN-1是TRCP6新型高效抑制剂，摘自专利WO

SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC₅₀ of 7.9 nM.

IC50: 7.9 nM (TRPC6 currents)^[3]

SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca²⁺ influx into cells with IC₅₀s of 9.5, 282 and 226 nM^[1][2][3], whereas TRPC4 and TRPC5-mediated Ca²⁺ entry is not affected. SAR7334 (1 μM) results in a major block of the Ang II-evoked calcium influx in the podocytes^[1]. SAR7334 (1 μM) has negligible effect on SOCE^[2]. SAR7334 dose-dependently reduces TRPC6 currents with an IC₅₀ of 7.9 nM. SAR7334 (100 nM) substantially reduces TRPC6 currents^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SAR7334 (10 mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

367.87

C₂₁H₂₂ClN₃O

1333210-07-3

Room temperature in continental US; may vary elsewhere.

DMSO : ≥ 370 mg/mL (1005.79 mM)

* "≥" means soluble, but saturation unknown.

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储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。