生物活性
KN-92 phosphate is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 phosphate is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a cell-permeable, reversible and competitive CaMKII inhibitor[1][2].
体外研究
(In Vitro)
KN-93 (5-50 μM; 24 hours) inhibits LX-2 cell growth and KN-92 (5-50μM; 24 hours) is ineffective in blocking cell growth[2].
The analysis of cell cycle regulator expression reveals that KN-93 rather than KN-92 reduced the expression of p53 and p21[2].
分子量
554.98
性状
Solid
Formula
C24H28ClN2O7PS
CAS 号
1135280-28-2
运输条件
Room temperature in continental US; may vary elsewhere.
溶解性数据
In Vitro:
DMSO : 50 mg/mL (90.09 mM; Need ultrasonic)
H2O : < 0.1 mg/mL (ultrasonic) (insoluble)
配制储备液
浓度溶剂体积质量 1 mg 5 mg 10 mg
1 mM 1.8019 mL 9.0093 mL 18.0187 mL
5 mM 0.3604 mL 1.8019 mL 3.6037 mL
10 mM 0.1802 mL 0.9009 mL 1.8019 mL
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: