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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1581270-11-2
- 规格：
10 mM * 1 mL/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2200.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥2000.0 |
| 规格： | 10 mg | 产品价格： | ￥3200.0 |
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RIP2 kinase inhibitor 2
CAS No. : 1581270-11-2
MCE 国际站：RIP2 kinase inhibitor 2
产品活性：RIP2 kinase inhibitor 2 是一种受体相互作用蛋白-2 (RIP2) 激酶抑制剂，详细信息请参考专利 WO/2014043437 A1 中的化合物 example 9。
研究领域：Apoptosis
作用靶点：RIP kinase
In Vitro: RIP2 kinase inhibitor 2 is a novel prodrug of a quinazolyl amine that inhibits RIP2 kinase. Receptor interacting protein-2 (RIP2) kinase is a TKL family serine/threonine protein kinase involved in innate immune signaling. Following activation, RIP2 kinase associates with NODI or NOD2 and appears to function principally as a molecular scaffold to bring together other kinases (TAK1, ΙΚΚα/β/γ) involved in NF-κΒ and mitogen-activated protein kinase activation.
相关产品：Bioactive Compound Library Plus | Apoptosis Compound Library | Kinase Inhibitor Library | NF-κB Signaling Compound Library | Anti-Cancer Compound Library | Protein-protein Interaction Inhibitor Library | Membrane Protein-targeted Compound Library | Serine/Threonine Kinase Inhibitor Library | Necrostatin-1 | GSK-872 | Necrostatin 2 racemate | GSK2982772 | GSK583 | GSK-843 | GSK840 | GSK547 | RIPA-56 | RIP1/RIP3/MLKL activator 1 | WEHI-345 | GSK2983559 | PROTAC RIPK degrader-2 | Apostatin-1 | GSK3145095 | HS-1371 | GSK2593074A | GSK963 | PROTAC RIPK degrader-6 | RIPK3-IN-1 | Eclitasertib | ICCB-19 hydrochloride | OD36 | GSK481 | PK68 | RIP1 kinase inhibitor 1
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文献和实验Kinase Inhibitor Profiling Using Chemoproteomics
Quantitative chemoproteomics has recently emerged as an experimental approach to determine protein interaction profiles of small molecules in a given cell line or tissue. In contrast to standard biochemical and biophysical kinase assays
Kinase Inhibitor Selectivity Profiling Using Differential Scanning Fluorimetry
and widely used approach is the direct measurement of the effect of the added ligands on its activity. A variety of enzymatic assay formats have been successfully applied for inhibitor screening of protein kinases. However, enzymatic assays require an active
Receptor Tyrosine Kinase Inhibitor Profiling Using Bead-Based Multiplex Sandwich Immunoassays
) as an example. We provide a protocol for a bead-based sandwich immunoassay that enables a relative quantification of the EGFR and its generic tyrosine phosphorylation. We also present data from a kinase inhibitor experiment using 96-well cell-culture plates
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