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| 规格： | 10 mM * 1 mL | 产品价格： | ￥3297.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1200.0 |
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CCG215022
CAS No. : 1813527-81-9
MCE 国际站：CCG215022
产品活性：CCG215022 是一种G蛋白偶联受体激酶 (GRK) 抑制剂，作用于 GRK2，GRK5 和 GRK1，IC50 分别为 0.15±0.07 μM，0.38±0.06 μM 和 3.9±1 μM。
研究领域：Stem Cell/Wnt
作用靶点：PKA
In Vitro: CCG215022 has nanomolar potency against both GRK2 and GRK5 and is at least 20-fold more potent than Paroxetine. In the course of a GRK2 structure-based drug design campaign, CCG215022 exhibits nanomolar IC50 values against both GRK2 and GRK5 and good selectivity against other closely related kinases such as GRK1 and PKA. Treatment of murine cardiomyocytes with CCG215022 results in significantly increases contractility at 20-fold lower concentrations than Paroxetine, an inhibitor with more modest selectivity for GRK2.
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文献和实验-------------------------------------------------------------------------- 748U19 Upper Primer 5' AAT GGT GGA CCG CAA CAA C 3' Length: 19-mer 5' 748 Tm: 65.7 °C (salt 1000.0 mM; oligo 100.0 pM) deltaG (25 °C): -37.6 kcal/mol Degeneracy: 1 P.E.#: 442/442 1/E: 5.24 nmol/A260 31.0 μg/A260
1 End TGA 6 0.81 0.4 Cys TGT 104 14.09 0.64 Cys TGC 58 7.86 0.36
40启动子（1） AP1 E3201 E3202 5`-CGC TTG ATG AGT CA G CCG GAA-3` 胶原酶基因TRE（2） AP2 E3211 E3212 5`-GAT CGA ACT GAC CGC CCG CGG C CC GT -3`人金属硫堇II a(3) 基因NF-kB E3291, E3292, 5`-AGT TGA GGG GAC TTT CC C AGG C-3`鼠Igk轻链基因（4） Oct1 E3241 E3242 5`-TGT CGA ATG
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