- ￥450 - 3950
- MedChemExpress(MCE)
- 美国
- HY-13307
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
相关阅读
阿拉丁试剂，充足现货，稳定批间差abinScience 体内级抗体，年度锁价，低至 1200五大应用案例：Mustang Q 膜层析应用全解析1 个小工具，一次性搞定流程图、质粒图谱和信号通路图- 详细信息
- 文献和实验
- 技术资料
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥495.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥450.0 |
| 规格： | 10 mg | 产品价格： | ￥750.0 |
| 规格： | 50 mg | 产品价格： | ￥2450.0 |
| 规格： | 100 mg | 产品价格： | ￥3950.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
JK184
CAS No. : 315703-52-7
MCE 国际站：JK184
产品活性：JK184 是一种有效的 Hedgehog (Hh) 抑制剂，在哺乳动物细胞中，IC50 为 30 nM。
研究领域：Stem Cell/Wnt
作用靶点：Hedgehog
In Vitro: JK184 is designed to antagonize Hh signaling by inhibiting glioma (Gli)-dependent transcriptional activity in a dose dependent manner. JK184 significantly inhibitts proliferation of HUVECs with IC50 of 6.3 μg/mL after three days incubation. To evaluate anti-tumor effect of JK184, MTT assay is conducted in Panc-1 and BxPC-3 cells after administration with indicated concentrations of compounds, half maximal inhibitory concentration (IC50) of JK184 (23.7 ng/mL in anc-1 and 34.3 ng/mL in BxPC-3). Claudin-low cell lines are more sensitive to JK184 treatment than are MCF10a, MTSV1-7, or HMLE-shGFP and HMLE-pBP cells, and JK184 induced a dose-dependent decrease in glioma-associated oncogene homolog 1 (GLI1) transcript and protein levels in these cells. Treatment with the IC50 dose of JK184 enhances the proportion of HMLE-shEcad cells that stained with Annexin-V, but are negative for propidium iodide (PI) (P<0.0001, t test).
In Vivo: JK184 (5 mg/kg, injected intravenously) exhibits good anti-proliferative activity in subcutaneous Panc-1 and BxPC-3 tumor models, and is a good candidate as antitumor drug targeted Hh signaling. However, JK184 has a poor pharmacokinetic profile and bioavailability.
相关产品：Bioactive Compound Library Plus | Stem Cell Signaling Compound Library | Wnt/Hedgehog/Notch Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Differentiation Inducing Compound Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Targeted Diversity Library | Anti-Liver Cancer Compound Library | Anti-Colorectal Cancer Compound Library | Cancer Stem Cells Compound Library | Membrane Protein-targeted Compound Library | Vismodegib | Cyclopamine | Itraconazole | Ciliobrevin D | SANT-1 | Dynarrestin | Ciliobrevin A | Hh-Ag1.5 | RU-SKI 43 hydrochloride | Jervine | Triparanol | CUR61414 | Neurodazine | 3-epi-Vitamin D3 | MK-4101 | SANT 2 | AZD8542 | Hedgehog IN-2 | Hedgehog IN-3 | Hedgehog IN-5 | HPP-9 | HSP70-IN-3 | Physalin H | RL-0070933 | Robotnikinin | RUSKI-201 dihydrochloride
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验耗功 率（W） 电 源电 压 控 温范 围 定 时范 围 外型尺寸 内腔尺寸 ZN17-JK52 700×530×520
Oxidative Stress and Beta Cell Dysfunction
Endocrinol Metabol 52:146–155, 2008; Pietropaolo M et al., Pediatr Diabetes 6:184–192, 2005).
，固有层水肿6例，血管扩张充血6例，另5例有大量淋巴细胞、浆细胞、多核粒细胞浸润。透射电镜检查23例，改变为壁细胞少，主细胞相对发达，未见潘氏细胞，腺管上皮细胞走行不规则，线粒体肿胀，粗面内质网扩张；个别细胞异形性较高、核畸形、分化较低。微需氧培养Hp52例。阳性率61.54%（32/52），另外活检粘膜1min尿素酶试验快速检测幽门螺杆菌（Hp）阳性率80.77%（42/52）。其中3例父母患胃病同时测Hp抗体阳性。 本组小儿胃炎型：浅表性胃炎657例，症状胃炎16例、糜烂性胃炎8例，出血
技术资料暂无技术资料 索取技术资料
