Saridegib,1037210-93-7

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Saridegib

CAS No. : 1037210-93-7

MCE 国际站：Saridegib

产品活性：Saridegib 是 Smo 的特异性有效抑制剂，这是 Hedgehog 通路中关键的跨膜信号蛋白。

研究领域：Stem Cell/Wnt

作用靶点：Smo

In Vivo: Evidence from a genetically engineered mouse model of pancreatic cancer demonstrates that Saridegib (IPI-926) can deplete tumor-associated stromal tissue and increase intratumoral mean vessel density. These changes result in enhanced delivery of concurrently administered systemic agents, leading to a decreased tumor burden and prolonged survival in this mouse model.

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