TDO抑制剂680c91

• 产品名称680C91
• 描述
  Potent， selective， substrate competitive tryptophan 2，3-dioxygenase inhibitor
• 生物学描述Potent, selective, substrate competitive tryptophan 2,3-dioxygenase inhibitor (K_i = 51 nM). Inhibits tryptophan catabolism. Increases brain tryptophan and serotonin levels in vivo.

性能

• 化学名称6-Fluoro-3-[(E)-2-pyridin-3-ylethenyl]-1H-indole
• 分子量238.26
• 化学结构
• 分子式C₁₅H₁₁FN₂
• CAS编号163239-22-3
• PubChem识别号10014426
• 存放说明Store at -20°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
• 溶解度概述Soluble in ethanol to 50 mM and in DMSO to 100 mM

• 680C91 (ab146153)参考文献

  This product has been referenced in:

• Salter M et al. The effects of a selective inhibitor of tryptophan 2,3-dioxygenase and a combined inhibitor of tryptophan 2,3-dioxygenase and 5-HT reuptake on serotonergic function in the rat. Adv Exp Med Biol 398:61-5 (1996). Read more (PubMed: 8906241) »
• Salter M et al. The effects of a novel and selective inhibitor of tryptophan 2,3-dioxygenase on tryptophan and serotonin metabolism in the rat. Biochem Pharmacol 49:1435-42 (1995). Read more (PubMed: 7539265) »
• Salter M et al. The effects of an inhibitor of tryptophan 2,3-dioxygenase and a combined inhibitor of tryptophan 2,3-dioxygenase and 5-HT reuptake in the rat. Neuropharmacology 34:217-27 (1995). Read more (PubMed: 7617147) »