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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 英文名：
CpG ODN 2006
- 供应商：
研卉生物
- 规格：
200ug
CpG ODNs
TLR9 Agonists
• CpG oligodeoxynucleotides (CpG ODN) or bacterial DNA
• Potent stimulators of immune cell maturation
• Purity and activity thoroughly validated
• Provided with endotoxin-free water
CpG ODNs are short synthetic single-stranded DNA molecules containing unmethylated CpG dinucleotides in particular sequence contexts (CpG motifs). CpG ODNs possess a partially or completely phosphorothioated (PS) backbone, as opposed to the natural phosphodiester (PO) backbone found in genomic bacterial DNA.
Three major classes of stimulatory CpG ODNs have been identified based on structural characteristics and activity on human peripheral blood mononuclear cells (PBMCs), in particular B cells and plasmacytoid dendritic cells (pDCs). These three classes are Class A (Type D), Class B (Type K) and Class C.
CpG ODNs
TLR9 Agonists
• CpG oligodeoxynucleotides (CpG ODN) or bacterial DNA
• Potent stimulators of immune cell maturation
• Purity and activity thoroughly validated
• Provided with endotoxin-free water
CpG ODNs are short synthetic single-stranded DNA molecules containing unmethylated CpG dinucleotides in particular sequence contexts (CpG motifs). CpG ODNs possess a partially or completely phosphorothioated (PS) backbone, as opposed to the natural phosphodiester (PO) backbone found in genomic bacterial DNA.
Three major classes of stimulatory CpG ODNs have been identified based on structural characteristics and activity on human peripheral blood mononuclear cells (PBMCs), in particular B cells and plasmacytoid dendritic cells (pDCs). These three classes are Class A (Type D), Class B (Type K) and Class C.
Class A CpG ODNs
| ODN 1585 | TLR9 Agonist - Stimulatory CpG ODN, Class A, Mouse-specific |
| ODN 2216 | TLR9 Agonist - Stimulatory CpG ODN, Class A, Human TLR9-selective |
| ODN 2336 | TLR9 Agonist - Stimulatory CpG ODN, Class A, Human preferred |
Class B CpG ODNs
| ODN 1668 | TLR9 Agonist - Stimulatory CpG ODN, Class B, Mouse specific |
| ODN 1826 | TLR9 Agonist - Stimulatory CpG ODN, Class B, Mouse-specific |
| ODN 2006 | TLR9 Agonist - Stimulatory CpG ODN, Class B, Human TLR9-selective |
| ODN 2007 | TLR9 Agonist - Stimulatory CpG ODN, Class B, Bovine / porcine |
| ODN BW006 | TLR9 Agonist - Stimulatory CpG ODN, Class B, Human & mouse |
| ODN D-SL01 | TLR9 Agonist - Stimulatory CpG ODN, Class B, Multispecies |
Class C CpG ODNs |
|
| ODN 2395 | TLR9 Agonist - Stimulatory CpG ODN, Class C, Human / mouse |
| ODN M362 | TLR9 Agonist - Stimulatory CpG ODN, Class C, Human / mouse |
| ODN D-SL03 | TLR9 Agonist - Stimulatory CpG ODN, Class C, Multispecies TLR9 ligand |
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- 作者
- 内容
- 询问日期
文献和实验Nature：癌症疫苗新突破！调动 T 细胞与 NK 细胞的双重攻击，全面杀灭癌细胞
-巨噬细胞集落刺激因子（GM-CSF）和佐剂 CpG ODN 1826 都被整合到该疫苗设计中。 图片来源：Nature 对转移性肿瘤的疗效 后续的实验结果表明，MICB α3 域疫苗（MICB-vax）可诱导高滴度的抗体，同时还能诱导 CD4+ T 细胞的增殖和增强 CD8+ T 细胞对 MICB 的反应。在体内，MICB-vax 可明显抑制 MICB 的脱落，并大大增加了细胞表面密度 MICB 的水平以及抗肿瘤作用。 图片来源：Nature 为了评估 MICB-vax 诱导的免疫记忆，在初次
Antisense Efficacy: Site-Restricted In Vivo and Ex Vivo Models
In the laboratory, antisense oligodeoxynucleotides (ODN) have repeatedly demonstrated efficacy in modulating the expression of various genes, thus providing important insights into their roles in tumorigenesis or normal growth and development
Modulation of human interferon- biosynthesis by antisense oligodeoxynucleotides
We investigated the inhibition of human interferon-γ (HuIFN-γ) production in cultures of lymphocytes with the use of the antisense strategy. Out of a series of antisense oligodeoxynucleotides (ODN) complementary to different regions of the HuIFN
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