- ￥1600 - 2650
- MultiSciences
- 3.13 pg/mL - 200 pg/mL
- 浙江杭州
- EK317-96
- 2025年12月03日
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- 文献和实验
- 技术资料
- 库存：
99
- 供应商：
联科生物
- 检测范围：
3.13 pg/mL - 200 pg/mL
- 检测方法：
双抗夹心法
- 应用：
ELISA
- 适应物种：
Rat
- 标记物：
HRP
- 样本：
血清，血浆，细胞培养上清及其他生物学样本
- 规格：
96T/48T
| 规格： | 96T | 产品价格： | ￥2650.0 |
|---|---|---|---|
| 规格： | 48T | 产品价格： | ￥1600.0 |
描述
| 商品名 |
Rat IL-17A ELISA Kit (大鼠白细胞介素17A ELISA试剂盒) |
|---|---|
| 检测方法 |
双抗夹心法 |
| 精密度 |
板内变异系数：3.9% - 7.1%；板间变异系数：3.0% - 3.9% |
| 样本类型 |
血清，血浆，细胞培养上清及其他生物学样本 |
| 检测样本体积 |
10 μL |
| 灵敏度 |
0.62 pg/mL |
| 检测范围 |
3.13 pg/mL - 200 pg/mL |
| 回收率 |
94% - 119% |
| 平均回收率 |
1.03 |
| 板式 |
96孔板，可拆 |
| 保存 |
试剂盒未拆开，4℃保存。已拆开，标准品-20℃保存，其它4℃保存。 |
| 运输条件 |
4℃蓝冰运输 |
| 组分 |
|
检测原理：本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗大鼠IL-17A抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体，经过孵育，样本中存在的IL-17A与固相抗体和检测抗体结合。洗涤去除未结合的物质后，加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中IL-17A的浓度成正比。加入终止液终止反应，在450 nm波长(参考波长570 - 630 nm)测定吸光度值。
IL17A 分子靶点信息概述
- 分子名：IL17A, interleukin 17A
- 基因家族：Interleukins
- 别名：IL-17A; IL-17
- 曾用名：CTLA8; IL17
- 全称：cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
IL17A 分子靶点综述
IL-17主要由Th17型细胞产生，是目前已发现的30余种白细胞介素中的一员，按序号排在第17位。该家族包括6个成员配体(IL-17A ~ IL-17F)和5个受体(IL-17RA ~ IL-17RD和SEF)。IL-17是一种主要由活化的T细胞产生的致炎细胞因子，可以促进T细胞的激活和刺激上皮细胞、内皮细胞、成纤维细胞产生多种细胞因子，从而导致炎症的产生。
大鼠 Rat Il17a 分子靶点信息
- 分子名：Il17a, interleukin 17A
- 别称：
- CTLA-8
- cytotoxic T-lymphocyte-associated antigen 8
- hypothetical protein LOC301289
- IL-17
- IL-17A
- Il17
- interleukin 17
- Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
- interleukin-17A
- LOC301289
- similar to Interleukin-17 precursor (IL-17) (Cytotoxic T lymphocyte-associated antigen 8) (CTLA-8)
- 基因序列：NCBI_Gene: 301289
- 蛋白序列：
- UniprotKB: G3V7M4
- UniprotKB: Q61453
大鼠 Rat Il17a 靶点分子功能（预测）
Predicted to enable protein heterodimerization activity and protein homodimerization activity. Involved in several processes, including cellular response to glucocorticoid stimulus; positive regulation of necrotic cell death; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and extracellular space. Used to study anti-basement membrane glomerulonephritis; congestive heart failure; myocarditis; pleurisy; and uveitis. Biomarker of several diseases, including acute necrotizing pancreatitis; inflammatory bowel disease (multiple); lipoid nephrosis; lung disease (multiple); and periodontal disease (multiple). Human ortholog(s) of this gene implicated in Mycobacterium avium complex disease; autoimmune disease (multiple); bronchial disease (multiple); macular degeneration; and rhinitis (multiple). Orthologous to human IL17A (interleukin 17A).
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文献和实验- IF = 9.587 Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain. Journal of Neuroinflammation (2022)
- IF = 7.446 Discovery and In Vivo Anti-inflammatory Activity Evaluation of a Novel Non-peptidyl Non-covalent Cathepsin C Inhibitor. JOURNAL OF MEDICINAL CHEMISTRY (2021)
- IF = 7.277 IL-17 crosses the blood–brain barrier to trigger neuroinflammation: a novel mechanism in nitroglycerin-induced chronic migraine. JOURNAL OF HEADACHE AND PAIN (2022)
- IF = 7.129 Probiotics ameliorates pulmonary inflammation via modulating gut microbiota and rectifying Th17/Treg imbalance in a rat model of PM2.5 induced lung injury. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)
- IF = 6.922 Qing-Luo-Yin Alleviated Experimental Arthritis in Rats by Disrupting Immune Feedback Between Inflammatory T Cells and Monocytes: Key Evidences from Its Effects on Immune Cell Phenotypes. Journal of Inflammation Research (2021)
- IF = 6.922 Securidaca inappendiculata-Derived Xanthones Protected Joints from Degradation in Male Rats with Collagen-Induced Arthritis by Regulating PPAR-γ Signaling. Journal of Inflammation Research (2021)
- IF = 5.811 Shenling Baizhu Powder Alleviates TNBS-Induced Colitis in Rats by Improving Intestinal Epithelial Permeability and Inhibiting Inflammation Through the TLR5/MyD88/NF-κB Pathway.. Frontiers in Pharmacology (2022)
- IF = 5.34 Isoforskolin, an adenylyl cyclase activator, attenuates cigarette smoke-induced COPD in rats. PHYTOMEDICINE (2021)
- IF = 5.31 Bortezomib alleviates antibody-mediated rejection in kidney transplantation by facilitating Atg5 expression. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)
- IF = 5.293 Gut Microbiota Is Involved in Alcohol-Induced Osteoporosis in Young and Old Rats Through Immune Regulation. Frontiers in Cellular and Infection Microbiology (2021)
- IF = 4.927 Physicochemical Characteristics and Antidiabetic Properties of the Polysaccharides from Pseudostellaria heterophylla. MOLECULES (2022)
- IF = 4.36 Metabolomics combined with network pharmacology to study the mechanism of Shentong Zhuyu decoction in the treatment of rheumatoid arthritis. JOURNAL OF ETHNOPHARMACOLOGY (2021)
- IF = 4.36 Tibetan medicine Ershiwuwei Lvxue Pill attenuates collagen-induced arthritis via inhibition of JAK2/STAT3 signaling pathway. JOURNAL OF ETHNOPHARMACOLOGY (2021)
- IF = 4.36 Yanning Syrup ameliorates the lipopolysaccharide-induced inflammation: Adjusting the gut microbiota, short-chain fatty acids, and the CD4+ T cell balance. JOURNAL OF ETHNOPHARMACOLOGY (2021)
- IF = 3.743 Modification effects of SanWei GanJiang Powder on liver and intestinal damage through reversing bile acid homeostasis. BIOMEDICINE & PHARMACOTHERAPY (2019)
- IF = 3.706 Dihydromyricetin Inhibits Inflammation of Fibroblast-like Synoviocytes through Regulation of NF-κB Signaling in Collagen-Induced Arthritis Rats. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2018)
- IF = 3.69 Ethyl acetate extract of Tibetan medicine Rhamnella gilgitica ameliorated type II collagen-induced arthritis in rats via regulating JAK-STAT signaling pathway. JOURNAL OF ETHNOPHARMACOLOGY (2020)
- IF = 3.47 Xanthones from Securidaca inappendiculata antagonized the antirheumatic effects of methotrexate in vivo by promoting its secretion into urine.. Expert Opinion on Drug Metabolism & Toxicology (2020)
- IF = 2.65 Iridoid from Eucommia ulmoides Oliv. Exerts Antiarthritis Effects by Inhibiting the JAK2/STAT3 Signaling Pathway In Vivo and In Vitro. Evidence-based Complementary and Alternative Medicine (2023)
- IF = 2.63 Traditional Chinese Medicine Aconiti Radix Cocta Improves Rheumatoid Arthritis via Suppressing COX-1 and COX-2. Evidence-based Complementary and Alternative Medicine (2021)
- IF = 2.064 Tou Nong San Attenuates Inflammation in TNBS-IBD Model by Inhibiting NF-κB Signaling Pathway. Evidence-based Complementary and Alternative Medicine (2018)
- IF = 1.984 Louqin Zhisou Decoction Inhibits Mucus Hypersecretion for Acute Exacerbation of Chronic Obstructive Pulmonary Disease Rats by Suppressing EGFR-PI3K-AKT Signaling Pathway and Restoring Th17/Treg Balance. Evidence-based Complementary and Alternative Medicine (2019)
- IF = 1.198 2-(-2-Benzofuranyl)-2-imidazoline reciprocally regulates Th17/Treg balance induced by ischemic stroke in rats. PHARMAZIE (2020)
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