华拓细胞库:RTE大鼠气管上皮细胞 Rat trachea epithelial cells were isolated from trachea tissue. Trachea, a part of the respiratory organ; It is cylindrical tubular with slightly flat back wall. The upper end is flat at the lower margin of the sixth cervical vertebra, connected with the cricoid cartilage; Down to the junction of the fourth and fifth thoracic vertebrae (equivalent to the sternal angular plane), the left and right main bronchus are divided, and the bifurcation is called the tracheal bifurcation. The trachea is mainly composed of 14-16 semi-cricoid cartilage, which is elastic. The cartilage is a "C" shaped cartilage ring, the notch is backward, and the cartilage rings are connected by ligaments. The gap behind the ring is connected by smooth muscle and dense connective tissue, maintaining a continuous opening state. The lumen is lined with mucous membranes and covered with ciliated epithelium. The mucous secreted by the mucous membranes can adhere to the dust particles in the inhaled air. The cilia constantly move to the pharynx to expel the mucous and dust to purify the inhaled gas. The tracheal epithelium is the first line of defense for the contact between the airway and the external environment. It is not only the target cells of various pathogens and inflammatory mediators, but also the effector cells that synthesize and release a variety of inflammatory mediators and cytokines to participate in airway inflammation and immune response. Primary tracheal epithelial cells cultured in vitro are very important in basic and research because of their similarities in morphology, structure and functional activities with tissues in vivo.
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