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- 文献和实验
- 技术资料
- 保存条件:
We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃.
- 保质期:
Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
- 英文名:
Recombinant Human Claudin-6 (CLDN6), partial
- 库存:
200
- 供应商:
武汉华美生物工程有限公司
- 规格:
20μg
英文名称:
Recombinant Human Claudin-6 (CLDN6), partial品名简称:
Recombinant Human CLDN6 protein, partial货号:
CSB-CF005508HU规格:
20μg价格:
5268LC-MS/Western Blot:
/SDS-PAGE:
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.纯度:
Greater than 90% as determined by SDS-PAGE.内毒素:
Not test生物活性:
/基因名:
CLDN6Uniprot No.:
P56747别名:
Skullin种属:
Homo sapiens (Human)蛋白长度:
Partial来源:
in vitro E.coli expression system分子量:
24.8 kDa表达区域:
1-82aa氨基酸序列:
MASAGMQILGVVLTLLGWVNGLVSCALPMWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARA蛋白标签:
N-terminal 6xHis-SUMO-tagged产品提供形式:
Liquid or Lyophilized powder缓冲液:
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.储存条件:
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.保质期:
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.货期:
3-7 business days注意事项:
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.功能1:
Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity). May act as a coreceptor for HCV entry into hepatic cells.功能2:
Plays a major role in tight junction-specific obliteration of the intercellular space.文献:
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003)研究领域:
Microbiology请点击“在线询价”找客服索取产品说明书及引用文献目录,产品实时更新参数、价格信息、更多文献信息可以查看cusabio官网
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文献和实验STM:广州医科大学刘铭/谢茂彬合作发现肝细胞癌的新潜在治疗靶点 Claudin 6
组于 Science Translational Medicine 杂志(STM)在线发表题为 Targeting tumor lineage plasticity in hepatocellular carcinoma using an anti-CLDN6 antibody-drug conjugate 的研究论文。这项研究揭示了细胞紧密连接(tight junction)蛋白 Claudin 6 通过调控肝癌细胞的谱系可塑性(lineage plasticity),促进肝癌进展与耐药的机制,并初步报道
国产CLDN18.2 ADC申报上市,晚期胃癌靶向治疗迎来新格局
)获国家药监局正式受理上市申请,用于至少两线治疗失败的CLDN18.2阳性晚期胃/胃食管交界处腺癌。该产品系集团首--款申报上市的ADC,也是全球第二款递交NDA的CLDN18.2靶向ADC,同时斩获FDA三项孤儿药资格,标志着国产CLDN18.2 ADC从研发迈向商业化的重要跨越。 关于CLDN18.2 Claudin-18 (CLDN18)是Claudin(CLDN)蛋白家族中的重要成员,肺和胃上皮细胞紧密连接的一个主要成分。CLDN18有两个
类器官文献解读:通透性驱动的压力与细胞增殖协同调控胰腺类器官管腔形态发生 !
通透性可使球型类器官向分支型转化 工具:非细胞毒性产气荚膜梭菌肠毒素片段(cCPE-647),通过结合闭合蛋白(claudin)破坏紧密连接,特异性增加上皮通透性。 急性效应:cCPE处理后,葡聚糖快速进入球型类器官管腔,随后管腔迅速塌陷、横截面积显著下降。 长期效应(第2–6天持续处理): 约50%的球型类器官转变为分支样表型,管腔占比显著下降、管腔数量显著增加; 总细胞数量无变化,证明形态改变不依赖增殖,由通透性-压力轴直接介导; 管腔静水压从对照组的36.8Pa降至处理组的7.6Pa,直接
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