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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃.
- 保质期:
Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
- 英文名:
Recombinant Human Claudin-6 (CLDN6), partial
- 库存:
200
- 供应商:
武汉华美生物工程有限公司
- 规格:
20μg
英文名称:
Recombinant Human Claudin-6 (CLDN6), partial品名简称:
Recombinant Human CLDN6 protein, partial货号:
CSB-CF005508HU规格:
20μg价格:
5268LC-MS/Western Blot:
/SDS-PAGE:
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.纯度:
Greater than 90% as determined by SDS-PAGE.内毒素:
Not test生物活性:
/基因名:
CLDN6Uniprot No.:
P56747别名:
Skullin种属:
Homo sapiens (Human)蛋白长度:
Partial来源:
in vitro E.coli expression system分子量:
24.8 kDa表达区域:
1-82aa氨基酸序列:
MASAGMQILGVVLTLLGWVNGLVSCALPMWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARA蛋白标签:
N-terminal 6xHis-SUMO-tagged产品提供形式:
Liquid or Lyophilized powder缓冲液:
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.储存条件:
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.保质期:
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.货期:
3-7 business days注意事项:
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.功能1:
Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity). May act as a coreceptor for HCV entry into hepatic cells.功能2:
Plays a major role in tight junction-specific obliteration of the intercellular space.文献:
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003)研究领域:
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文献和实验STM:广州医科大学刘铭/谢茂彬合作发现肝细胞癌的新潜在治疗靶点 Claudin 6
组于 Science Translational Medicine 杂志(STM)在线发表题为 Targeting tumor lineage plasticity in hepatocellular carcinoma using an anti-CLDN6 antibody-drug conjugate 的研究论文。这项研究揭示了细胞紧密连接(tight junction)蛋白 Claudin 6 通过调控肝癌细胞的谱系可塑性(lineage plasticity),促进肝癌进展与耐药的机制,并初步报道
PNAS 重磅:高盐饮食也能有益健康,它对自身免疫性疾病有显著的保护作用
首先关注了先前报道的免疫系统的改变。但是在肠道与脾脏中并没有发现任何免疫类型的细胞具有显著的改变。于是,推测 HSD 在自发性与主动诱导的实验性自身免疫脑脊髓炎中的不同,可能是由于改变了 BBB 的结果,而蛋白表达结果显示 HSD 喂养组脑内皮细胞的 BBB 连接分子 ZO-1 和 claudin-5 的表达显著升高。因此,研究人员将目光主要集中在可能改变 BBB 的循环组分上。 图片来源:PNAS 在人类与小鼠中,高盐的摄取会导致盐皮质激素和糖皮质激素水平发生改变,检测发现 HSD 组小鼠
axis orchestrates polycystic ovary syndrome ③ Sci Rep:杀死癌症的种子 —— 破坏癌症干细胞有效治疗乳腺癌当医生用外科手术切除肿瘤,或用化疗药物或放射疗法治疗肿瘤时,肿瘤可能会消失。然而,有证据表明,一小部分适应性强的肿瘤细胞能够存活并在体内循环,在遥远的地方播下新的转移的种子。托莱多大学的科学家们研究了一种常用化疗药物的改进方法,他们发现了一种全新的抗癌药物,有望根除癌症干细胞。研究人员发现,他们的药物在单用治疗肉瘤和一种被称为 Claudin
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