PPAR靶基因PCR基因芯片 PPAR Targets PC

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PPAR Targets PCR Array

PPAR靶基因PCR基因芯片

Product	Species	Technology	Cat. No.
PPAR Targets PCR Array	Human	Gene Expression	PAHS-149Z
PPAR Targets PCR Array	Mouse	Gene Expression	PAMM-149Z
PPAR Targets PCR Array	Rat	Gene Expression	PARN-149Z

PPAR Targets RT² Profiler PCR Array profiles the expression of 84 key genes involved in peroxisome proliferator-activated receptor (PPAR) activation and response. The PPARs are nuclear hormone receptors important in regulating lipid metabolism, cellular differentiation, and proliferation. The 3 PPAR isoforms have similar functions but different tissue distributions: alpha (adipose tissue, liver, and muscle), beta/delta (widely-expressed), and gamma (adipose tissue and muscle). Ligands such as fatty acids activate these receptors causing them to heterodimerize with the retinoid X receptors (RXR) and initiate transcription of target genes. Multiple different coactivators and corepressors interact with the PPAR/RXR heterodimers to direct target gene specificity. Dysregulation of PPAR activity is a potential cause of metabolic syndrome-related disorders, such as insulin resistance and hypercholesterolemia. This array includes PPAR targets involved in adipogenesis, lipid transport and metabolism, and insulin signaling. Genes involved in PPAR ligand transport as well as transcription factors and cofactors are also included. Using real-time PCR, research studies can easily and reliably analyze the expression of a focused panel of genes involved in PPAR signal transduction with this array.
PPAR靶基因PCR基因芯片可以同时检测参与过氧化物酶增殖物激活受体（PPAR）活化和响应的84个关键基因的表达。PPARs是重要的核激素受体，参与调节脂质代谢，细胞分化和增殖。3种PPAR的亚型都具有类似的功能，但具有特定的组织分布特性：α（脂肪组织，肝脏和肌肉）；β/δ（广泛表达）；γ（脂肪组织和肌肉）。被配体（如脂肪酸）激活的受体可以与类视黄醇X受体（RXR）形成异源复合体，启动相关靶基因的转录。众多不同的共激活因子和抑制因子直接参与调解PPAR/RXR异二聚体的靶基因的表达。PPAR活性的失调是众多代谢综合征相关的疾病（比如胰岛素抵抗和高胆固醇血症）的可能因素。该芯片包括参与脂肪胞分化,脂质转运和代谢，胰岛素信号的PPAR靶基因。同时，参与PPAR配体转运以及相关转录因子和辅因子基因也包括在内。利用实时定量PCR，研究者可以方便并且可信地对PPAR的信号转导相关基因进行同时检测。
PPARα Targets:
Adipogenesis:ADIPOQ, LPL, NR1H3, UCP1.
Fatty Acid Metabolism:ACADL, ACADM, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, CPT1A, CPT1B, CPT2, CYP27A1, CYP4A11, CYP7A1, EHHADH, FADS2, HMGCS2, PLTP, SCD.
Lipid Transport:ADIPOQ, ANGPTL4, APOA1, APOA5, APOC3, LPL, NR1H3, OLR1.
Insulin Signaling:CPT1A, SORBS1.
PPARβ/δ Targets:
Adipogenesis:ADIPOQ, ECH1, FABP4, LPL, UCP1.
Fatty Acid Metabolism:ACAA2, ACADL, ACADM, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, CPT1A, CPT1B, CPT2, CYP4A11, CYP27A1, CYP7A1, EHHADH, ETFDH, FABP1, FABP3, FABP4, FADS2, GK, HMGCS2, MLYCD, PLTP, SCD, SLC27A1, SLC27A4.
Lipid Transport:ADIPOQ, ANGPTL4, LPL, OLR1.
Cell Proliferation:HIF1A, ILK, KLF10, PTEN.
Insulin Signaling:CPT1A, PDPK1, SORBS1.
Others:PDPK1.
PPARγ Targets:
Adipogenesis:ADIPOQ, LPL, NR1H3, UCP1.
Fatty Acid Metabolism:ACADL, ACADM, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, CPT1A, CPT1B, CPT2, CYP27A1, CYP4A11, CYP7A1, EHHADH, FADS2, GK, SCD.
Lipid Transport:ADIPOQ, ANGPTL4, APOE, DGAT1, LPL, NR1H3, OLR1.
Cell Proliferation:CLU, ELN, TXNIP.
Insulin Signaling:CPT1A, DGAT1, PCK1, PCK2, SORBS1.
Others:MMP9, PCK1, PCK2.
PPAR Cofactors:CHD9, CREB1, CREBBP, EP300, FGR, LPIN1, MED1, NCOA3, NCOA6, PPARGC1A (PGC-1a), PPARGC1B (PGC-1?), PPRC1, HELZ2, SIRT1, SMARCD3, SRC, TGS1.
PPAR Ligand Transport:CD36, FABP1, FABP2, FABP3, FABP4, FABP5, FABP6, FABP7, SLC22A5, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6.
PPAR Transcription Factors:PPARA, PPARD, PPARG, RXRA, RXRB, RXRG