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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Human recombinant CTLA-4
- 亚型:
IgG2
- 形态:
Liquid
- 保存条件:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
- 克隆性:
Monoclonal
- 标记物:
Unconjugated
- 适应物种:
Human
- 保质期:
12 months from the shipping date of the product.
- 抗原来源:
Human
- 目录编号:
GTX52659
- 级别:
Primary Antibodies
- 库存:
Available
- 供应商:
GeneTex
- 宿主:
Mouse
- 应用范围:
WB
- 浓度:
500 μg/ml (Please refer to the vial label for the specific concentration.)
- 靶点:
CTLA4
- 抗体英文名:
CTLA4 antibody [8F16]
- 抗体名:
CTLA4 抗体 [8F16]
- 规格:
100 μg
WB analysis of HEK293 overexpressing human CTLA-4 using GTX52659 CTLA4 antibody [8F16].
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文献和实验【翻译】Development trends for monoclonal antibody cancer therapeutics
). However, since 2000, humanized and human mAbs have been entering clinical study at approximately the same rate (4.3 versus 4.5 mAbs per year, respectively). Figure 1 | Categories of monoclonal antibody cancer therapeutics entering clinical study during 1980–1989
Nature 综述导读:FDA 批准第 100 个抗体药物!抗体药物的研究方向在哪里?
仍超过 50 亿美元。 图七 Journal of Biomedical Science (2020) 27:1来自抗体协会 (Antibody Society) 的数据显示,临床管道中也存在类似的大量内卷现象。目前有将近 870 种抗体在临床开发中,但其中大约 36% 的抗体集中在下表二的 10 个靶点中。PD1/PDL1、HER2、CTLA4、EGFR 和 CD20 仍然占据较高的比例。 表二:Nature Reviews Drug Discovery 20, 10 (2021)癌症将继续占据
protocols involving costimulation blockade have recently been developed. The prototypical murine protocol described in this chapter, involves the use of CTLA4Ig and a monoclonal antibody-specific for CD154 (CD40L) for costimulation blockade, 3 Gy
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