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- 文献和实验
- 技术资料
- 免疫原:
STAT1 peptide sequence 721-733 (DNLLPMSPEEFDE).
- 亚型:
IgG2b
- 形态:
Liquid
- 保存条件:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
- 克隆性:
Monoclonal
- 标记物:
Unconjugated
- 适应物种:
Human, Mouse
- 保质期:
12 months from the shipping date of the product.
- 抗原来源:
Human
- 目录编号:
GTX23987
- 级别:
Primary Antibodies
- 库存:
Available
- 供应商:
GeneTex
- 宿主:
Mouse
- 应用范围:
WB, IHC-P, IP
- 浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
- 靶点:
This antibody recognizes an epitope included within amino acids 721-733 of STAT1.
- 抗体英文名:
STAT1 antibody [SM1]
- 抗体名:
STAT1 抗体 [SM1]
- 规格:
100 μg
WB analysis of human malignant melanoma cells (short-term culture derived from a patient) treated with IFN-gamma (10 ng/ml) and IFN-alpha (1000 IU/ml and 5000 IU/ml) using GTX23987 STAT1 antibody [SM1].
Upper Lane : GTX23991 STAT1 (phospho Ser727) antibody [PSM1]
Lower Lane : GTX23987 STAT1 antibody [SM1]
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文献和实验:赖氨酸丙酮酰化示意图 4月,电子科技大学医学院郑慧团队在《Cell》首次报道了丙酮酰化,聚焦丙酮酸介导的免疫信号调控机制。 研究证实,糖酵解终产物丙酮酸可共价修饰免疫关键蛋白STAT1的K201位点,该位点处于STAT1‑STAT2蛋白互作界面,发生丙酮酰化后会产生空间位阻,直接阻断异二聚体的组装,进而抑制I型干扰素(IFN‑I)信号通路,下调干扰素刺激基因ISG的表达,削弱机体抗病毒免疫能力。 定量检测显示,细胞葡萄糖浓度升高时,伴随糖酵解通路激活,STAT1‑K201位点丙酮酰化修饰占比可由约
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members, including fibrillarin and nucleolin, involved in ribosomal biogenesis, histones, fibroblast growth factor, interleukin enhancer-binding factor 3 the SRC kinase adapter protein Sam68, STAT1, and EWS. Analysis of protein arginine methylation
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