- ￥3220 - 21030
- Sino Biological
- 北京
- 10084-H08H
- 2025年08月12日
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- 文献和实验
- 技术资料
- 保存条件：
-20℃ to -80℃
- 保质期：
12个月
- 英文名：
Recombinant Human PD-L1 / B7-H1 / CD274 Protein (His Tag)
- 库存：
99
- 供应商：
北京义翘神州科技股份有限公司
- 规格：
1.00 mg/100.00 µg/200.00 µg
| 规格： | 1.00 mg | 产品价格： | ￥21030.0 |
|---|---|---|---|
| 规格： | 100.00 µg | 产品价格： | ￥3220.0 |
| 规格： | 200.00 µg | 产品价格： | ￥3870.0 |
重组人 PD-L1 / B7-H1 / CD274 蛋白 (His标签)（产品说明）
蛋白名称：Human PD-L1 / B7-H1 / CD274 Protein (His Tag)
蛋白构建：A DNA sequence encoding the N-terminal segment (Met 1-Thr 239) of the extracellular domain of human B7-H1 (NP_054862.1) was expressed with a C-terminal polyhistidine tag.
表达宿主：HEK293 Cells
蛋白纯度：> 98 % as determined by SDS-PAGE
蛋白活性：1. Measured by its binding ability in a functional ELISA. Immobilized human B7-H1 at 20 μg/ml (100 μl/well) can bind human PD1 with a linear range of 0.032-0.8 μg/ml. 2. Using the Octet RED System, the affinity constant (Kd) of PD-1 Protein, Human, Recombinant (Fc Tag) (Cat. 10377-H02H) bound PD-L1 Protein, Human, Recombinant (His Tag) (Cat. 10084-H08H) was 19.2nM.
蛋白内毒素：< 1.0 EU per μg of the protein as determined by the LAL method
预测N端：Phe 19
蛋白分子量：The recombinant mature human B7-H1 comprises 232 amino acids and predicts a molecular mass of 26.8 kDa. As a result of glycosylation, the human B7-H1 migrates as an approximately 35-38 kDa protein in SDS-PAGE under reducing conditions.
蛋白NP号：NP_054862.1
蛋白氨基酸序列：Met1-Thr239
蛋白标签：C-His
蛋白保存条件：Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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文献和实验1, Schofield DJ, et al. Activity of murine surrogate antibodies for durvalumab and tremelimumab lacking effector function and the ability to deplete regulatory T cells in mouse models of cancer.mAbs, PubMed ID: 33397194
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3, Xing Y, et al. New electrochemical method for programmed death-ligand 1 detection based on a paper-based microfluidic aptasensor.Bioelectrochemistry (Amsterdam, Netherlands), PubMed ID: 33677221
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6, Banta KL, et al. Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses.Immunity, PubMed ID: 35263569
7, He B, et al. PDL1Binder: Identifying programmed cell death ligand 1 binding peptides by incorporating next-generation phage display data and different peptide descriptors.Frontiers in microbiology, PubMed ID: 35910615
8, Yi M, et al. Anti-TGF-β/PD-L1 bispecific antibody promotes T cell infiltration and exhibits enhanced antitumor activity in triple-negative breast cancer.Journal for immunotherapy of cancer, PubMed ID: 36460337
9, Parkinson J, et al. The RESP AI model accelerates the identification of tight-binding antibodies.Nature communications, PubMed ID: 36709319
10, Wang F, et al. Identification of CBPA as a New Inhibitor of PD-1/PD-L1 Interaction.International journal of molecular sciences, PubMed ID: 36835382
11, Zhang Y, et al. Preclinical development of novel PD-L1 tracers and first-in-human study of [68Ga]Ga-NOTA-RW102 in patients with lung cancers.Journal for immunotherapy of cancer, PubMed ID: 38580333
12, Yao Y, et al. Construction and preclinical evaluation of a 124I-labelled bispecific antibody targeting PD-L1 and PD-L2.European journal of nuclear medicine and molecular imaging, PubMed ID: 39155310
13, Xu X, et al. A Novel Monoclonal Antibody against PD-1 for the Treatment of Viral Oncogene-Induced Tumors or Other Cancer.Cancers, PubMed ID: 39272910
14, Mao C, et al. In situ editing of tumour cell membranes induces aggregation and capture of PD-L1 membrane proteins for enhanced cancer immunotherapy. Nature communications, PubMed ID:39521768
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