- ￥3000 - 3999
- Abbiotec
- 美国
- 250726
- 2025年07月12日
- E, WB, IHC
- Rabbit
- H, M, R
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human IRS-1.
- 亚型：
Rabbit Ig
- 形态：
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
- 保存条件：
Store at -20°C.
- 克隆性：
多克隆抗体
- 标记物：
见下方详细说明
- 适应物种：
H, M, R
- 宿主：
Rabbit
- 应用范围：
E, WB, IHC
- 浓度：
见详细说明信息
- 靶点：
IRS-1
- 抗体英文名：
IRS-1 Antibody
- 抗体名：
IRS-1 Antibody
- 规格：
0.1 mg
IRS-1 Antibody产品详细介绍：
| 产品名称： | IRS-1 Antibody |
| 说明书： | http://www.abbiotec.com/antibodies/irs-1-antibody【参考图片】 |
| 货号： | 250726 |
| 规格： | 0.1 mg |
| 产品描述： | The family of insulin receptors substrates (IRSs) has been reported to play an important role for signal transduction of various hormones. Four members of the IRS family have been described. Each IRS is believed to have different functions; however the distinct physiological roles of each IRS are unclear. IRS-1 may mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor, IRS-1 binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit, ROCK1, UBTF and PIK3CA. Serine phosphorylation (Ser-312) of IRS-1 is a mechanism for insulin resistance. Polymorphisms in IRS-1 may be involved int he etiology of non-insulin-dependent diabetes mellitus. |
| 克隆类型： | Rabbit Polyclonal Antibody |
| 亚型： | Rabbit Ig |
| 免疫原： | KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human IRS-1. |
| 适用物种： | H, M, R |
| 应用范围： | E, WB, IHC |
| 应用说明： | E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
| 别名： | IRS-1; Insulin receptor substrate 1; IRS-1; IRS1 |
| 形态： | Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存条件： | Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 参考文献： |
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文献和实验Bacterial Expression of IRS-1 containing GST-fusion Proteins
1. Grow cells in 5ml (or more) of LB-Amp overnight for a starter culture. 2. Grow larger culture using the overnight culture as a seeding culture. The culture is grown in LB-Amp medium. Aerate well with shaking at 37 C until OD at 600nm
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
The importance of antibody molecules was first recognized in the 1890s, when it was shown that immunity to tetanus and diphtheria was caused by antibodies against the bacterial exotoxins (1 ). Around the same time, it was shown that antisera
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