TALEs (Transcription Activator-Like Effectors) are proteins that bind to DNA in a sequence-specific way. By fusing such a TALE to a Nuclease (a "TALENs"), a highly specific DNA scissor is made. The TALENs technology has become a powerful approach for genome editing in a number of animal models.In just over several years of operation, Creative Animodel has provide TALENs products and services for the generation and analysis of genetically modified rodent models. We have generated more than 50 custom models and provided services to clients at over 28 different institutions worldwide. http://www.creative-animodel.com/Animal-Model-Development/Conditional-Knockout.html