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10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥495.0 |
| 规格： | 10 mg | 产品价格： | ￥700.0 |
| 规格： | 25 mg | 产品价格： | ￥1313.0 |
| 规格： | 50 mg | 产品价格： | ￥2100.0 |
| 规格： | 100 mg | 产品价格： | ￥2940.0 |
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Leupeptin hemisulfate
CAS No. : 103476-89-7
MCE 国际站：Leupeptin hemisulfate
产品活性：Leupeptin hemisulfate 是一种广谱的、具有细胞膜渗透性的蛋白酶抑制剂。 Leupeptin hemisulfate 能有效抑制丝氨酸、半胱氨酸和苏氨酸蛋白酶。 Leupeptin hemisulfate 能抑制 Mpro (SARS-CoV-2 的主要蛋白酶)，还具有抗炎活性。
研究领域：Metabolic Enzyme/Protease | Anti-infection
作用靶点：Cathepsin | Ser/Thr Protease | Virus Protease
In Vitro: Leupeptin hemisulfate (0.06-200 µM; 72 h) significantly decreases copy numbers of SARS-CoV-2 viral RNA (vRNA) in Vero cells
Leupeptin hemisulfate inhibits RNA levels of SARS-CoV-2 in Vero cells, with an EC50 value of 42.34 µM.
Leupeptin hemisulfate has some inhibitory activity against Mpro, with an IC50 value of 127.2 µM.
Leupeptin hemisulfate againsts human coronavirus strain 229E with an IC50 value of 0.4 µg/mL (about 1 µM).
In Vivo: Leupeptin hemisulfate (0, 9, 18, 36 mg/kg; i.p.; single) is well tolerated by the animals and produces a strong, dose-dependent increase in LC3b-II in both the total tissue extracts and the lysosome and autophagosome-enriched pellet fraction.
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