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10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥495.0 |
| 规格： | 10 mg | 产品价格： | ￥700.0 |
| 规格： | 25 mg | 产品价格： | ￥1313.0 |
| 规格： | 50 mg | 产品价格： | ￥2100.0 |
| 规格： | 100 mg | 产品价格： | ￥2940.0 |
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Leupeptin hemisulfate
CAS No. : 103476-89-7
MCE 国际站：Leupeptin hemisulfate
产品活性：Leupeptin hemisulfate 是一种广谱的、具有细胞膜渗透性的蛋白酶抑制剂。 Leupeptin hemisulfate 能有效抑制丝氨酸、半胱氨酸和苏氨酸蛋白酶。 Leupeptin hemisulfate 能抑制 Mpro (SARS-CoV-2 的主要蛋白酶)，还具有抗炎活性。
研究领域：Metabolic Enzyme/Protease | Anti-infection
作用靶点：Cathepsin | Ser/Thr Protease | Virus Protease
In Vitro: Leupeptin hemisulfate (0.06-200 µM; 72 h) significantly decreases copy numbers of SARS-CoV-2 viral RNA (vRNA) in Vero cells
Leupeptin hemisulfate inhibits RNA levels of SARS-CoV-2 in Vero cells, with an EC50 value of 42.34 µM.
Leupeptin hemisulfate has some inhibitory activity against Mpro, with an IC50 value of 127.2 µM.
Leupeptin hemisulfate againsts human coronavirus strain 229E with an IC50 value of 0.4 µg/mL (about 1 µM).
In Vivo: Leupeptin hemisulfate (0, 9, 18, 36 mg/kg; i.p.; single) is well tolerated by the animals and produces a strong, dose-dependent increase in LC3b-II in both the total tissue extracts and the lysosome and autophagosome-enriched pellet fraction.
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文献和实验【求助】求助！！关于EMSA核蛋白提取过程中用到的100x Protease Inhibitor
月下独见 我最近打算提核蛋白做EMSA，我是自己配制的buffer，其中要加入100x Protease Inhibitor使buffer里含有1x Protease Inhibitor。这个100x Protease Inhibitor有没有买的？还是要自己配制。 我查了一下资料Protease Inhibitor里含有Aprotinin Leupeptin Pepstatin PMSF，如果自己配Protease Inhibitor的话以上的试剂
TGEK Base 50 mM Tris 10% vol Glycerol 1 mM EDTA 100 mM KCl (add for std lysis buffer): PMSF Benzamidine Leupeptin Aprotinin 0.5% NP40 (add for solubilization buffer) 1% NP40 0.1% Triton X100 0.1% SDS 0.5% NaDeoxycholate Buffer
Too many bands on a Western blot
. Addition of protease inhibitors such as PMSF, pepstatin or leupeptin should be considered. Too much protein per lane or detection system too sensitive . Overloading of the gel is one of the most common reasons for "ghost bands
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