NADPH tetrasodium salt,2646-71

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

NADPH tetrasodium salt

CAS No. : 2646-71-1

MCE 国际站：NADPH tetrasodium salt

产品活性：NADPH tetrasodium salt 是多种代谢和生物合成途径中的重要辅助因子 (cofactor)。NADPH tetrasodium salt 在药物、手性醇、脂肪酸和生物聚合物的生物合成中起着至关重要的作用，同时也是脂质生物合成、生物量形成和细胞复制所必需的。对 NADPH 的需求在增殖的癌细胞中特别高，在那里它作为核苷酸、蛋白质和脂肪酸合成的辅助因子。NADPH tetrasodium salt 对于中和代谢活性增加产生的高水平活性氧 (ROS) 也是必不可少的。NADPH tetrasodium salt 是一种内源性的 ferroptosis 抑制剂。

研究领域：Apoptosis | Metabolic Enzyme/Protease

作用靶点：Ferroptosis | Endogenous Metabolite

In Vitro: NADPH tetrasodium salt de novo synthesis is catalyzed by NAD kinases (NADKs), which catalyze the phosphorylation of NAD⁺ to form NADP⁺. NADPH tetrasodium salt is mainly involved in catabolic reactions, whereas NADPH tetrasodium salt is primarily involved in cellular antioxidative effects and anabolic reactions. NADPH tetrasodium salt is used by glutathione reductase (GR) to reduce oxidized glutathione (GSSG) to GSH.
The regeneration rate of NADPH tetrasodium salt is often the rate-limiting step for the over-production of desired chemicals, while maintaining robust cellular growth.
NADPH tetrasodium salt homeostasis is regulated by varied signaling pathways and several metabolic enzymes that undergo adaptive alteration in cancer cells. The metabolic reprogramming of NADPH tetrasodium salt renders cancer cells both highly dependent on this metabolic network for antioxidant capacity and more susceptible to oxidative stress.
NADPH tetrasodium salt is an essential intracellular reductant needed to eliminate lipid hydroperoxides. Indeed, NADPH tetrasodium salt levels are a biomarker of ferroptosis sensitivity across many cancer cell lines.

相关产品：Bioactive Compound Library Plus | Apoptosis Compound Library | Metabolism/Protease Compound Library | Anti-Cancer Compound Library | Human Endogenous Metabolite Compound Library | Anti-Aging Compound Library | Nucleotide Compound Library | Oxygen Sensing Compound Library | Ferroptosis Compound Library | Food-Sourced Compound Library | Rapamycin | 3-Methyladenine | Ferrostatin-1 | Erastin | Cisplatin | RSL3 | Acetylcysteine | Deferoxamine mesylate | Cycloheximide | 5-Fluorouracil | Sorafenib | SP600125 | Necrostatin-1 | ATP | ML385 | Retinoic acid | AICAR | Hydrocortisone | Rosiglitazone | Estradiol | Docetaxel | Nicotinamide | Liproxstatin-1 | Melatonin | Isoprenaline hydrochloride | Prostaglandin E2 | Cytarabine | Curcumin | Acetaminophen | Capsaicin

热门产品线：重组蛋白 | 化合物库 | 天然产物 | 染料试剂 | PROTAC | 同位素标记物 | 寡核苷酸

Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds | Oligonucleotides

品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
• 设有专业的实验中心和严格的质控、验证体系；
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
• 产品的生物活性多经各国客户实验验证；
• Nature, Cell, Science 等多种TOP期刊及制药专利收录了MCE客户的科研成果；
• 专业团队跟踪前沿的制药及生命科学研究进展，为您提供全球前沿的活性化合物；
• 与世界各大制药公司及知名科研机构建立了长期的合作。