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文献和实验and stored in granules. An example is histamine. Other mediators are generated de novo , e.g., eicosanoids. Mast cells and basophils produce some important cytokines, e.g., IL-4, IL-13, TNF-α (1 –5 ) and the chemokines MlP-1α and RANTES
Mast Cell Histamine and Cytokine Assays
Mast cells are crucial to the development of chronic allergic inflammation and are likely to play a critical role in host defense. In this chapter methodology for histamine and cytokine assays is provided. Crosslinkage of IgE receptor I (Fcε
Histamine N-Methyltransferase: Enzymology and Functional Aspects
Histamine N -methyltransferase (HNMT; EC 2.1.1.8) was discovered a little over 25 yr ago. Since that time, HNMT has been the subject of numerous investigations, and although these studies have provided a fundamental understanding of this enzyme
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