- ￥185 - 2680
- TargetMol
- 美国
- T0866
- 2025年07月12日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
Propafenone
- 库存：
10
- 供应商：
TargetMol
- CAS号：
54063-53-5
- 规格：
50 mg/100 mg/10 mg/200 mg/25 mg/500 mg/5 mg/1 mL
| 规格： | 50 mg | 产品价格： | ￥662.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥1070.0 |
| 规格： | 10 mg | 产品价格： | ￥258.0 |
| 规格： | 200 mg | 产品价格： | ￥1580.0 |
| 规格： | 25 mg | 产品价格： | ￥413.0 |
| 规格： | 500 mg | 产品价格： | ￥2680.0 |
| 规格： | 5 mg | 产品价格： | ￥185.0 |
| 规格： | 1 mL | 产品价格： | ￥227.0 |
Product Introduction
Bioactivity
英文名:Propafenone
描述:Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. The electrophysiological effect of propafenone manifests itself in a reduction of upstroke velocity (Phase 0) of the monophasic action potential. In Purkinje fibers, and to a lesser extent myocardial fibers, propafenone reduces the fast inward current carried by sodium ions, which is responsible for the drugs antiarrhythmic actions. Diastolic excitability threshold is increased and effective refractory period prolonged. Propafenone reduces spontaneous automaticity and depresses triggered activity. At very high concentrations in vitro, propafenone can inhibit the slow inward current carried by calcium but this calcium antagonist effect probably does not contribute to antiarrhythmic efficacy.
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文献和实验useful drugs, including metoprolol, propafenone, haloperrdol, dextromethorphan and codeine (1 ). Quinidine competrtively inhibits CYP2D6, with a K1 of 3-30 mM (3 –5 ). Because of its preferential inhibition of CYP2D6 (6 7 ), quinidine is frequently
律（mexiletine）口服首剂400～600mg，维持量150～300mg，6～8小时给药1次。静脉注射：开始量30～250mg或75～300mg/5～30分钟内注完，然后静脉滴注1.5～3g/36～48小时。 盐酸妥卡尼（tocainide hydrochloride）0.4～0.6g/次，3次/日，口服。 氟卡尼（flecainide）口服200mg/次，2～3次/日。静脉注射1～2mg/kg,缓慢注入。 普罗帕酮（propafenone）口服150mg/次，2～4次/日，维持量150
67 16 2.7 1.9 3.0 异丙嗪 promethazine - - 70～80 18 13 12 普罗帕酮 propafenone 3～40
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