Gemifloxacin甲磺酸吉米沙星,210353-53-

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Gemifloxacin mesylate

CAS No. : 210353-53-0

MCE 国际站：Gemifloxacin mesylate

产品活性：Gemifloxacin mesylate (SB-265805S; LB-20304a) 是一种具有口服活性的广谱性喹诺酮类抗菌抗生素 (antibiotic)。Gemifloxacin mesylate 通过抑制 DNA 旋回酶 (DNA gyrase) 和拓扑异构酶 IV (Topoisomerase IV) 活性抑制DNA合成 (DNA synthesis)。Gemifloxacin mesylate 对革兰氏阳性菌有较强的体外抑菌活性，特别是链球菌 (Streptococci) 和葡萄球菌 (Staphylococci)。Gemifloxacin mesylate 已被用于呼吸道感染的研究。

研究领域：Anti-infection  |  Cell Cycle/DNA Damage

作用靶点：Bacterial  |  Antibiotic  |  DNA/RNA Synthesis  |  Topoisomerase

In Vitro: Gemifloxacin has higher antibacterial activity than Moxifloxacin (HY-66011A) against Streptococcus pneumoniae with a MIC₉₀ of 0.06 μg/mL.
Gemifloxacin has highly potent antibacterial activity against Penicillin-resistant strains of S. pneumoniae with a MIC₉₀ of 0.03 μg/mL.

In Vivo: Gemifloxacin has favorable pharmacokinetic profile in animals after oral administration.
Pharmacokinetic Parameters of Gemifloxacin in Sprague-Dawley rats and dogs.

Species	Administration	AUC0-24 (μg/mL·h)	Half-life (h)	Cmax (μg/mL)	Tmax (h)	F (%)
Rat	p.o.; 20 mg/kg	8.50	2.33	2.44	0.33	95.3
Dog	p.o.; 4 mg/kg	7.55	5.12	1.34	1.13	71

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