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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
SKF-92334
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
51481-61-9
- 规格：
10 mM * 1 mL/100 mg/1 g/5 g/10 g
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥350.0 |
| 规格： | 1 g | 产品价格： | ￥500.0 |
| 规格： | 5 g | 产品价格： | ￥840.0 |
| 规格： | 10 g | 产品价格： | ￥1050.0 |
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Cimetidine
CAS No. : 51481-61-9
MCE 国际站：Cimetidine
产品活性：Cimetidine (SKF-92334) 是一种具有口服活性的，可逆的组胺 H2 受体拮抗剂，Ki 为 0.6 μM。Cimetidine 是一种胃酸减少剂，可用于十二指肠和胃溃疡研究。Cimetidine 具有抗癌和抗炎活性。
研究领域：GPCR/G Protein | Neuronal Signaling | Immunology/Inflammation | Anti-infection
作用靶点：Histamine Receptor | Bacterial
In Vitro: Cimetidine (SKF-92334), a partial agonist for H2R, has a pharmacological profile different from ranitidine and famotidine, possibly contributing to its antitumor activity on gastrointestinal cancers [1]. Cimetidine had no effect on the uptake and cytotoxicity of cisplatin in ovarian cancer cells with high OCT2 mRNA levels (IGROV-1 cells).
Cimetidine showed no effect on proliferation, survival, migration and invasion of 3LL cells. Cimetidine reversed MDSC-mediated T-cell suppression, and improved IFN-γ production.
Cimetidine-mediated down-regulation of NCAM involved suppression of the nuclear translocation of NF-kappaB, a transcriptional activator of NCAM gene expression.
In Vivo: Cimetidine (SKF-92334) reduceS CD11b(+)Gr-1(+) myeloid derived-suppressive cell (MDSC) accumulation in spleen, blood and tumor tissue of tumor-bearing mice.
Cimetidine exerts a beneficial effect on periodontal disease in rats, decreasing the RANKL/OPG ratio in gingival connective tissue and reducing alveolar bone resorption.
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文献和实验20世纪80年代初，西咪替丁(Cimetidine)也用于免疫增强，西眯替了通过与Ts细胞的H2受体结合，可以阻止组胺对丁s细胞的活化作用，从而增强机体的免疫功能。
2．西咪替丁（cimetidine） 是一种组胺拮抗剂，可与组胺2（HZ）受体结合，竞争性地抑制组胺的作用，临床主要用于 胃及十二指肠溃疡 治疗。80年代初，由于发现TS细胞表面具有H2受体；组胺与TS细胞的H2受体结合后，可使TS细胞活化而抑制机体的免疫功能。西咪替丁通过与TS细胞的H2受体结合，可以阻止组胺对TS细胞的活化作用，从而增强机体的免疫功能。研究表明，西咪替丁可以增强正常或免疫缺损小鼠的免疫功能，并能明显抑制肿瘤的生长。 左旋
治 疗 前 治 疗 后 伴胃炎数 活动性炎 炎症减轻(％) 活动性炎消失(％) CBS 60 29 55/60(92) 29/29(100) 西咪替丁 52 25 32/52(61) 15/25(60) 雷尼替丁 50 22 30/50(60) 11/22(50) 3 讨论 清除Hp感染已成为治疗 慢性胃炎 及消化性溃疡的重要措施。本组观察结果证明CBS对Hp清除率为95％，西咪替丁为23％，雷尼替丁为22％
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