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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
154-17-6
- 规格：
500 mg/1 g/5 g/10 g
| 规格： | 500 mg | 产品价格： | ￥400.0 |
|---|---|---|---|
| 规格： | 1 g | 产品价格： | ￥500.0 |
| 规格： | 5 g | 产品价格： | ￥1488.0 |
| 规格： | 10 g | 产品价格： | ￥2550.0 |
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2-Deoxy-D-glucose
CAS No. : 154-17-6
MCE 国际站：2-Deoxy-D-glucose
产品活性：2-Deoxy-D-glucose 是一种葡萄糖类似物，为葡萄糖代谢抑制剂，通过作用于己糖激酶 (hexokinase) 来抑制糖酵解 (glycolysis)。
研究领域：Metabolic Enzyme/Protease | Anti-infection | Apoptosis
作用靶点：Hexokinase | HSV | Apoptosis
In Vitro: 2-Deoxy-D-glucose (2-DG, 4, 8, or 16 mM) significantly reduces the level of ATP in MCF-7 cells in a dose- and time-dependent manner that paralleles the effects of 2-DG on cell growth. The levels of phosphorylated Akt are significantly decreased, whereas the levels of phosphorylated AMPK and Sirt-1 are significantly increased in MCF-7 cells exposed to 2-Deoxy-D-glucose at 4, 8, or 16 mM for 1, 3, or 5 days in a dose- and time-dependent manner. 2-DG treatment increases the levels of pentose phosphate pathway (PPP) metabolites and augments the generation of NADPH by glucose-6-phosphate dehydrogenase. An increase in NADPH and upregulation of glutathione synthetase expression resultes in the increase in the reduced form of glutathione by 2-DG in NB4 cells.
In Vivo: 2-Deoxy-D-glucose (0.03%, w/w) causes a 7% decrease in final weight that is statistically significant, and delayes the appearance of palpable mammary carcinomas. 2-Deoxy-D-glucose (3 mmol/kg, i.v.) is decreased in a dose-dependent manner in rat muscle.
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文献和实验Measurement of Cell Membrane Toxicity by Means of 2-Deoxy-D-Glucose
The membrane theory of toxicity (1 ) emanates from the fact that the plasma membrane is the first barrier met by a toxic agent on reaching the cell, and was first advanced to explain the toxic effects of heavy metals. The vital regulatory
一种己糖胺。 D-半乳糖胺与 D-葡糖胺是 4-差向异构体，常用的化学系统名是 2-氨基 -2-脱氧 -D-半乳糖（ 2－ amino－ 2－ deoxy－ D－ galactose）。在自然界其作为构成动物细胞和组织支持物质的糖蛋白和蛋白多糖的组成糖（以 N-乙酰半乳糖胺的形态）是广泛存在的。
The TALLYHO Mouse as a Model of Human Type 2 Diabetes
, and hyperlipidemia. Glucose intolerance and hyperglycemia are exhibited only in males. Reduced 2-deoxy-glucose uptake occurs in adipose tissue and skeletal muscle of male TH mice. While both sexes of TH mice exhibit enlarged pancreatic islets, only males
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