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- 2025年12月05日
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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
211555-04-3
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥900.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥511.0 |
| 规格： | 10 mg | 产品价格： | ￥818.0 |
| 规格： | 50 mg | 产品价格： | ￥3497.0 |
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WHI-P154
CAS No. : 211555-04-3
MCE 国际站：WHI-P154
产品活性：WHI-P154 是一种有效的 EGFR 抑制剂，同时可适度的抑制 JAK3 的活性，IC50 值分别为 4 nM 和 1.8 μM。
研究领域：JAK/STAT Signaling | Protein Tyrosine Kinase/RTK | Epigenetics | Stem Cell/Wnt | Apoptosis
In Vitro: WHI-P154 is a potent EGFR inhibitor, and also modestly blocks JAK3, with IC50s of 4 nM and 1.8 μM, respectively. WHI-P154 significantly enhances the sensitivity of ABCG2-overexpressing cells to its substrates. WHI-P154 (4 μM) moderately sensitizes ABCB1-overexpressing KB-C2 cells to its substrates whereas shows no sensitizing effect on ABCC1-, ABCC2 or ABCC10-mediated drug resistance. Moreover, WHI-P154 (4 μM) causes a significant increase in the intracellular accumulation of [3H]-mitoxantrone in ABCG2-overexpressing cells. WHI-P154 alters the expression levels rather than the localization of the ABCG2 protein in ABCG2-overexpressing cells.
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文献和实验(35% vs. 71%) [4]。 Section.04 ADC 的设计 为了尽可能提高药物的有效性和安全性，在设计 ADC 时必须考虑几项关键要素，包括靶点的选择、靶向特异性抗体、有效载荷以及连接子。 产品推荐 ABBV-3373 (HY-164894) www.medchemexpress.cn/abbv-3373.html ADC Adalimumab (HY-P9908
174/HinfⅠ φχ174/Hae Ⅲ φχ174/TapⅠ 1631 726 140 1353 2914 517 713 118 1078 1175 506 553 100 872 404 396 500 82 603 327 344 417 66 310 231 298 413 48 281 141 221 311 42 271 87 220 249 40 234 54 154 200 24 194 33 75 151 118
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