- ￥500
- MedChemExpress(MCE)
- 美国
- HY-18738
- 2025年07月11日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
Ammonium pyrrolidinedithiocarbamate; PDTC ammonium; APDC
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
5108-96-3
- 规格：
100 mg
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Pyrrolidinedithiocarbamate ammonium
CAS No. : 5108-96-3
MCE 国际站：Pyrrolidinedithiocarbamate ammonium
产品活性：Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidinedithiocarbamate) 是选择性和具有血脑屏障通透性的 NF-κB 抑制剂。
研究领域：NF-κB
作用靶点：NF-κB
In Vitro: Pretreatment of cells with Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidinedithiocarbamate; 3-1000 μM) dose-dependently attenuate IL-8 production.
Furthermore, pyrrolidinedithiocarbamate ammonium (100 μM) suppresses the accumulation of IL-8 mRNA.
Pyrrolidinedithiocarbamate ammonium inhibits the activation of NF-κB, because it suppresses both NF-κB DNA binding and NF-κB-dependent transcriptional activity. NF-κB inhibition with pyrrolidinedithiocarbamate ammonium decrease IL-8 production by intestinal epithelial cells.
In Vivo: The DSS+pyrrolidinedithiocarbamate ammonium-treated groupII exhibits suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels are significantly lower in DSS+pyrrolidinedithiocarbamate ammonium-treated groupII. These findings suggest that suppression of NF-κB activity by pyrrolidinedithiocarbamate ammonium can delay the healing of mucosal tissue defects (erosions or ulcers) arising from inflammation, but that it can strongly suppress the expression of inf-lammatory cytokines (IL-1β and TNF-α), resulting in significant alleviation of colitis. pyrrolidinedithiocarbamate ammonium is useful for the treatment of ulcerative colitis.
相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Phorbol 12-myristate 13-acetate | Bortezomib | BAY 11-7082 | TAK-243 | JSH-23 | Sulfasalazine | Shikonin | Triptolide | Aspirin | Dihydroartemisinin | Baicalin | Parthenolide | BAY 11-7085 | 5-Aminosalicylic Acid | CBL0137 hydrochloride | Rocaglamide | Betulinic acid | Isoginkgetin | SN50 | SC75741 | QNZ | Andrographolide | Astaxanthin | Hyperoside | 20(S)-Ginsenoside Rg3 | B022 | Lidocaine | Withaferin A | (-)-DHMEQ | E3330
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验Ammonium Sulfate Binding Assay for Cells
1. Resuspend cells (vegetative or developed) in phosphate buffer at 1 x 10 8 /ml . 2. Add 50 ul cells to 50 ul 20 nM 3H-cAMP in 5-10 mM DTT (for background binding, add same amount of hot cAMP plus 10 uM cold cAMP) in 1.5 ml eppendorf tube
Antibody Purification: Ammonium Sulfate Fractionation or Gel Filtration
Antibodies can be purified by a variety of methods based on their unique physical and chemical properties such as size, solubility, charge, hydrophobicity and binding affinity. This chapter focuses on ammonium sulfate precipitation
Purification of Antibodies Using Ammonium Sulfate Fractionation or Gel Filtration
In this chapter, two commonly used techniques that are utilized in many immunoglobulin purification schemes are described. The first procedure, ammonium sulfate fractionation, is generally employed as the initial step in the isolation of crude
技术资料暂无技术资料 索取技术资料
